Sökning: "receptor antagonism"

Visar resultat 6 - 10 av 59 avhandlingar innehållade orden receptor antagonism.

1. 6. Effects of neuroactive steroids on the recombinant GABAA receptor in Xenopus oocyte

   Författare :Mozibur Rahman; Ming-De Wang; Bjarke Ebert; Umeå universitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; GABA; GABAA receptor; neuroactive steroids; Obstetrics and gynaecology; Obstetrik och gynekologi;

   Sammanfattning : Introduction: Neuroactive steroids represent a class of both synthetic and naturally occurring steroids that have an effect on neural function. In addition to classical genomic mechanism by the hormones progesterone, deoxycorticosterone and testosterone 3α-OH metabolites of these hormones enhance GABAA receptor through rapid non-genomic mechanism. LÄS MER

3. 7. Tolerance and antagonism to allopregnanolone effects in the rat CNS

   Författare :Sahruh Turkmen; Inga-Maj Johansson; Agneta Nordberg; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; GABA-A receptor; UC1011; Spatial memory; Morris Water Maze; Tolerance; Silent second; mRNA; Obstetrics and gynaecology; Obstetrik och gynekologi;

   Sammanfattning : Many studies have suggested a relationship between sex steroids and negative mental and mood changes in women. Allopregnanolone, a potent endogenous ligand of the GABA-A receptor and a metabolite of progesterone, is one of the most accused neuroactive steroids. LÄS MER

4. 8. Neuropeptide Y Y1 receptor mechanisms in sympathetic vascular control

   Författare :Rickard E Malmström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Sympathetic vasoconstriction; neuropeptide Y1 Y; receptor antagonists; BIBP 3226; SR 120107A; ischaemia; pig.;

   Sammanfattning : It was demonstrated that the Y1 receptor was the predominant vascular neuropeptide Y (NPY) receptor in pig kidney and hind limb as exogenous and endogenous NPY evoked vasoconstrictor responses that were almost or totally abolished by the selective non-peptide Y1 receptor antagonist, BIBP 3226. Furthermore, renal vasoconstriction was evoked by NPY and a peptide Y1 agonist, but not by a Y 2 agonist, and these responses were strongly reduced by another non-peptide Y, receptor antagonist, SR 120107A. LÄS MER

5. 9. Molecular mechanisms of transcriptional repression by the orphan receptor SHP

   Författare :Ann Båvner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Nuclear receptor; repression; small heterodimer partner; co-regulator;

   Sammanfattning : SHP (Small Heterodimer Partner) is an atypical orphan member of the mammalian nuclear receptor family that consists of only a putative ligand-binding domain and thus cannot bind DNA. The aim of this thesis was to investigate the molecular mechanisms of the transcriptionally inhibitory effect of SHP. LÄS MER

7. 10. Brain glycine receptors as a common target for alcohol and the relapse-preventing drug acamprosate - a preclinical study

   Författare :Pei Pei Chau; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcoholism; Acamprosate; Glycine receptor; Preclinical study; Dopamine; Ethanol;

   Sammanfattning : Alcohol abuse and dependence make up the most prevalent categories of substance use disorders in the world. Converging evidence from the current research group has identified two receptor populations, the glycine (GlyRs) and nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system, as two potentially important targets for the development of new medication to treat alcohol dependence. LÄS MER