Sökning: "receptor antagonism"

Visar resultat 1 - 5 av 59 avhandlingar innehållade orden receptor antagonism.

  1. 1. Progesterone metabolites : learning, tolerance, antagonism & metabolism

    Författare :Charlotte Öfverman; Inga-Maj Johansson; Torbjörn Bäckström; Esa Korpi; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allopregnanolone; isoallopregnanolone; THDOC; learning; tolerance; antagonism; inhibition; patch clamp; Morris water maze; metabolism; epimerization; Obstetrics and gynaecology; Obstetrik och gynekologi; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Progesterone metabolites as allopregnanolone, isoallopregnanolone and tetrahydrodeoxy-corticosterone (THDOC) are increased in the luteal phase of the menstrual cycle, throughout pregnancy and during stress. Allopregnanolone and THDOC are neurosteroids with 3α-hydroxy, 5α-configurations and positive modulating effect on the GABAA receptor. LÄS MER

  3. 2. Molecular basis of estrogen receptor antagonism

    Författare :Nina Heldring; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen Receptor; antagonism; receptor signaling; phytoestrogen and conformational changes;

    Sammanfattning : Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined effects of accessory proteins, known as coregulators, promoter characteristics and influence from other signaling systems, determine the cell-specific transcriptional response in a given situation. LÄS MER

  4. 3. Cardiovascular risk factors in renal artery stenosis : Effects of renal angioplasty and angiotensin II receptor antagonism

    Författare :Elzbieta Nowakowska-Fortuna; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; renovascular hypertension; endothelin 1; apolipoprtoein C-III; brain natriuretic peptides; angiotensin II receptor antagonism; renal angioplasty; atherosclerotic renal artery stenosis;

    Sammanfattning : Renovascular hypertension (RVH) caused by atherosclerotic renal artery stenosis (ARAS) is one of the most common forms of secondary hypertension. The prognosis for patients with RVH is much worse compared to patients with primary hypertension, and caused by a high cardiovascular morbidity. LÄS MER

  5. 4. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

    Författare :Charlotta Wallinder; Anders Hallberg; Mathias Alterman; Anders Karlén; Elizabeth E. Sugg; Uppsala universitet; []
    Nyckelord :AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

    Sammanfattning : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. LÄS MER

  7. 5. Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock

    Författare :Anna Somell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :sepsis; endotoxin; fluid resuscitation; hypertonic saline dextran; endothelin; tezosentan;

    Sammanfattning : Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due to hypoperfusion and inflammatory changes. LÄS MER