Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Towards new computational tools for predicting toxicity

    Författare :Swapnil Chavan; Ian Nicholls; Scott Boyer; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Acute toxicity; chronic toxicity; hERG; k-NN; LD50; LOEL; Munro database; QSAR; read-across; toxicity; Medicinsk kemi; Medical Chemistry;

    Sammanfattning : The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. LÄS MER

  3. 2. Persistency, bioaccumulation and toxicity assessment of selected brominated flame retardants

    Författare :Jenny Rattfelt Nyholm; Patrik L. Andersson; Peter Haglund; Mats Tysklind; Walter Vetter; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; persistence; bioaccumulation; toxicity; biodegradation; biotransformation; PBT; read across; soil; earthworm; zebrafish; copepod; BFRs; polybrominated diphenyl ethers; tetrabromobisphenol A; hexabromocyclododecane; hexabromobenzene; 2; 4; 6-tribromophenol; tetrabromobisphenol A; 2-hydroxyethyl ether; 1; 2-dibromo-4- 1; 2-dibromoethyl cyclohexane; Environmental chemistry; Miljökemi;

    Sammanfattning : Brominated flame retardants (BFRs) are chemicals used in e.g. electronic equipment, textiles and plastics for the prevention of fire. Over recent decades, concern has been raised regarding some heavily used BFRs, since the levels in the environment have been increasing. LÄS MER

  4. 3. Transcriptomics and bioconcentration studies in fish to identify pharmaceuticals of environmental concern

    Författare :Filip Cuklev Stern; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fish; microarray; bioconcentration; pharmaceuticals; wastewater treatment; environment;

    Sammanfattning : Pharmaceuticals are frequently found in the aquatic environment. As they are most often highly biologically active, quite persistent and may accumulate in aquatic organisms, i.e. bioconcentrate, they may pose a risk to non-target organisms. LÄS MER

  5. 4. In silico tools in risk assessment : of industrial chemicals in general and non-dioxin-like PCBs in particular

    Författare :Mia Stenberg; Patrik Andersson; Miriam Jacobs; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; industrial chemicals; in silico tools; molecular descriptors; non-dioxin-like PCBs; partial least-squares PLS ; principal component analysis PCA ; quantitative structure-activity relationship QSAR ; REACH; risk assessment RA ; statistical molecular design; structure-activity relationship SAR ;

    Sammanfattning : Industrial chemicals in European Union produced or imported in volumes above 1 tonne annually, necessitate a registration within REACH. A common problem, concerning these chemicals, is deficient information and lack of data for assessing the hazards posed to human health and the environment. LÄS MER

  7. 5. Stainless Steel in Biological Environments – Relation between Material Characteristics, Surface Chemistry and Toxicity

    Författare :Yolanda Hedberg; Inger Odnevall Wallinder; Sasha Omanovich; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Triggered by the regulatory need of the industry to demonstrate safe use of their alloy products from an environmental and health perspective, and by the significant lack of metal release data and its correlation to material and surface characteristics for iron- and chromium-based alloys, a highly interdisciplinary in-depth research effort was undertaken to assess the relation between material/surface characteristics and toxicity with main emphasis on stainless steel alloys. This thesis focuses predominantly on studies made on AISI 316L both as massive sheet and as powder particles, but includes also results for other stainless steel grades and reference metals and metal oxides. LÄS MER