Sökning: "reactive astrocytes"

Visar resultat 21 - 25 av 47 avhandlingar innehållade orden reactive astrocytes.

  1. 21. New neurons and astrocytes in the adult brain. Studies on adult rat neural progenitors in vivo and in vitro with special reference to the effects of IGF-I and CNTF regarding proliferation and lineage determination

    Författare :Maria A I Åberg; Göteborgs universitet; []
    Nyckelord :Brain; hippocampus; rat; neurogenesis; progenitor cell; stem cell; ciliary neurotrophic factor; insulin-like growth factor-I; PI3-K; MAPK.;

    Sammanfattning : The hippocampal dentate gyrus in several species, including man, continues to produce new neurons and glial cells in adulthood. The generation of new neurons and glial cells in the adult hippocampus is under strict regulation. Two major events of significance for cell genesis from progenitor cells are proliferation and lineage determination. LÄS MER

  3. 22. Recovery from focal brain ischemia induced by extradural compression in diabetic and non-diabetic rats

    Författare :Tiago J T Prazeres Moreira; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Focal ischemia; locomotor activity; lever-press task; neurodegeneration; hyperglycemia; Goto-Kakizaki rats; Fluoro-Jade; heme-oxygenase; astrocytes; microglia.;

    Sammanfattning : Cerebrovascular disease and head trauma are among the leading causes of death and disability. In addition to severe motor disturbances, ischemia resulting from stroke or traumatic brain injury (TBI) can cause mild to severe cognitive deficits. LÄS MER

  4. 23. Astrocytic communication and cell death during metabolic depression and oxidative stress

    Författare :Christina Nodin; Göteborgs universitet; []
    Nyckelord :astrocyte; gap junction; ATP; ROS; oxidative stress; Annexin V; AIF; programmed cell death; Nrf2; scavenger; iodoacetate; SIN-1;

    Sammanfattning : Stroke is a major cause of death and adult disability in the western world. Most often, stroke is caused by the occlusion of a brain artery. Within the perfusion territory of the occluded vessel, various degrees of necrotic and delayed programmed cell death will occur if the occlusion persists, leading to expanding tissue damage. LÄS MER

  5. 24. Immune regulation within the central nervous system and its role in demyelinating diseases

    Författare :Bao-Guo Xiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), are diseases of the central nervous system (CNS) characterized by perivascular mononuclear inflammation and oligodendrocyte loss with demyelination. However, it is still not clear whether the pathology in MS and EAE is due to neuroantigen-specific CD4+ T cell-mediated autoimmune responses and/or bystander myelin damage resulting from an inflammatory response. LÄS MER

  7. 25. Glial cell responses, complement and clusterin expression after lesions in central or peripheral nervous system

    Författare :Li Liu; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Glia; Complement; Clusterin; Proliferation; Peripheral nerve injury; Spinal cord injury; Rhizotomy; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : The present Thesis examines the expression and role of complement and the complement regulator clusterin after central or peripheral axon injury in relation to the responses of non-neuronal cells. Following peripheral sensory nerve injury, complement was expressed in the spinal cord and brain stem in association with reactive microglia, which also appeared to be a local source of complement. LÄS MER