Sökning: "reactive astrocytes"

Visar resultat 11 - 15 av 47 avhandlingar innehållade orden reactive astrocytes.

  1. 11. NEURAL STEM/PROGENITOR CELLS IN THE POST-ISCHEMIC ENVIRONMENT: Proliferation, Differentiation and Neuroprotection

    Författare :Jonas Faijerson; Göteborgs universitet; []
    Nyckelord :neural stem cells; neural progenitor cells; stroke; ischemia; reactive astrocytes; astrogliosis; proliferation; differentiation; neurogenesis; excitotoxicity; transfection; neuroprotection;

    Sammanfattning : Stroke is one of the leading causes of chronic disability and death in the Western world. Today, no treatment can repair the cellular loss associated with an ischemic lesion. LÄS MER

  3. 12. HIF-dependent Signaling Pathways in Cancer

    Författare :Elinn Johansson; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Hypoxia; ccRCC; glioma; CD44; Notch1; reactive astrocytes;

    Sammanfattning : The cellular response to hypoxia, primarily orchestrated by hypoxia-inducible factors (HIFs; mainly HIF-1α and HIF-2α), is at the center of several signaling pathways conferring aggressive tumor behavior. HIFs may be crucially involved in tumor initiation, as seen in clear cell renal cell carcinoma, as well as maintenance of resistance cancer stem cell phenotypes, as observed in glioma. LÄS MER

  4. 13. Role of classical pro- and anti-inflammatory mediators in ischemic stroke. Beyond neuroimmunomodulation

    Författare :Ana Inacio; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; interferon-β; inflammatory immune cells; galectin-3; experimental stroke; enriched environment; cytokines; Brain; macrophage migration inhibitory factor; neuroprotection; reactive astrocytes.;

    Sammanfattning : Stroke is a leading cause of death and long-term neurological deficits worldwide, and no effective treatment is available for the vast majority of the stroke patients. A rapid and persistent activation of multiple and dynamic inflammatory and immune cascades, in and outside the brain, occurs after stroke. LÄS MER

  5. 14. Reactive gliosis in the injured brain: The effect of cell communication and Nrf2-mediated cellular defence

    Författare :Heléne Andersson; Göteborgs universitet; []
    Nyckelord :Keywords: astrocyte; gap junction; Hmox1; microglia; Nrf2; Nqo1; oxidative stress; reactive gliosis;

    Sammanfattning : Stroke and other brain injuries trigger an extensive glial cell response referred to as reactive gliosis. Reactive gliosis is characterized by hypertrophic and proliferating astrocytes, proliferating microglia and NG2-positive cells, which eventually form a bordering glial scar around the damaged area. LÄS MER

  7. 15. On astrocytes and neural stem cells : a study of reactive and canonical neurogenesis

    Författare :Margherita Zamboni; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The mammalian central nervous system has limited regenerative capacity and the long-lasting functional impairment resulting from trauma and neurodegenerative disease derives from a failure to repopulate neuronal cell populations that are lost to injury. The studies included in the present thesis aim at proposing astrocytes as a novel source for achieving widespread replacement of neurons. LÄS MER