Sökning: "rat neurons"

Visar resultat 1 - 5 av 271 avhandlingar innehållade orden rat neurons.

  1. 1. The role of reactive oxygen species in traumatic brain injury : Experimental studies in the rat

    Författare :Niklas Marklund; Uppsala universitet; []
    Nyckelord :Medical sciences; Apoptosis; CBF; controlled cortical contusion injury; 3; 4-dihydroxybenzoate; fluid percussion injury; glucose; 4-hydroxybenzoate; microdialysis; Morris Water Maze; neuroprotection; nitrones; PBN; rat; reactive oxygen species ROS ; salicylate; S-PBN; TBI; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury (TBI) is a major cause of mortality and disability. As common sequelae in survivors of TBI are disabling functional, emotional and cognitive disturbances, improved treatment of TBI patients is urgently needed. At present, no neuroprotective pharmacological treatment exists. LÄS MER

  2. 2. Nanowires and Neural interfaces. Biocompatibility in the brain

    Författare :Lina Gällentoft; NanoLund; []
    Nyckelord :neural interface; neurons; BMI; nanowires; tissue responses; rat; biocompatibility; astrocytes; microglia;

    Sammanfattning : Chronic neural interfaces that are able to record or stimulate neurons in the CNS are valuable instruments in use today and they hold great promise for the future both within neuroscience research and in the clinic. However, a major obstacle is that they show a decline in performance over time. LÄS MER

  3. 3. On dopamine neurons : nerve fiber outgrowth and L-DOPA effects

    Författare :Sara af Bjerkén; Ingrid Strömberg; Kathy Steece-Collier; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; GDNF; L-DOPA; L-DOPA induced dyskinesia; Neurobiology; Neurobiologi;

    Sammanfattning : Parkinson’s disease is a disorder mainly characterized by progressive degeneration of dopamine producing neurons in the substantia nigra of the midbrain. The most commonly used treatment strategy is to pharmacologically restore the lost function by the administration of the dopaminergic precursor L-DOPA. LÄS MER

  4. 4. Pituitary adenylate cyclase activating polypeptide : Expression and neurotrophic activity in the rat brain

    Författare :Ylva Skoglösa; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; in situ hybridisation; rat; TBI; BDNF; NGF; GDNF; PACAP; PRI; TUNEL; apoptosis; CNS; PNS; neuropeptides; neurotrophic factors; reactive oxygen species; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Neurotrophic factors play an important role in regulating naturally occurring cell death during neurogenesis. In addition to classical neurotrophic factors, some neurotransmitters and neuropeptides have been shown to exhibit neurotrophic activities. LÄS MER

  5. 5. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Författare :Anders Lewén; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. LÄS MER