Sökning: "rare DNA"

Visar resultat 1 - 5 av 131 avhandlingar innehållade orden rare DNA.

  1. 1. Advances in DNA Detection

    Författare :Yajing Song; Olof Emanuelsson; Jonas Tegenfeldt; KTH; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; DNA detection; active filter paper; visual detection; throughput; fluorescence; superparamagnetic beads; rare DNA; Q-PCR; chemical fragmentation; DNA library preparation; massively parallel sequencing; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Sammanfattning : DNA detection technologies have an increasing importance in our everyday lives, with applications ranging from microbial diagnostics to forensic analysis, food safety evaluation, and environmental monitoring. Currently, as the associated costs decrease, DNA diagnostic techniques are routinely used in research laboratories, in clinical and forensic practice. LÄS MER

  2. 2. Repair of DNA double-stranded breaks in human cells

    Författare :Susanne Nyström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA-PK; DNA double-stranded break; DSB; DNA single-stranded break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin gamma1; bleomycin; etoposide; topoisomerase II; radiotherapy; radiosensitizer; ATM;

    Sammanfattning : DNA is continuously subjected to degradation. Therefore, our cells need to constantly repair its DNA to prevent mutations and in the long run cancer. In mammalian cells, when DNA is broken right off, a double-stranded break (DSB) is produced, and the ends are ligated by a process called non-homologous end-joining (NHEJ). LÄS MER

  3. 3. Dried blood sampling and digital readout to advance molecular diagnostics

    Författare :Johan Björkesten; Ulf Landegren; Björn Högberg; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; molecular diagnostics; dried blood sample; DBS; digital readout; digital enumeration; DNA detection methods; proximity extension assay; protein stability; genotyping; rare mutations; cell free DNA; multiplex protein measurement.; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : A drastically increased capacity to measure large sets of molecular features in numerous patient samples in great detail will be required to fulfill the vision of precision medicine and wellness, which may characterize molecular diagnostics in the 21st century. Also sampling procedures need a renaissance to permit continuous sampling at population levels at reasonable cost. LÄS MER

  4. 4. Molecular Genetic Studies of the Blood Group ABO Locus in Man

    Författare :Martin L Olsson; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chi sequence; recombination; population studies; blood group serology; erythrocyte; blood transfusion; sequencing; DNA; PCR; genomic; Blood group ABO; allele; Immunology; serology; transplantation; Immunologi; serologi; Clinical genetics; Klinisk genetik;

    Sammanfattning : The ABO blood group system is undoubtedly the most important genetic and phenotypic marker in clinical transfusion medicine. The A and B determinants are immunodominant, terminally located carbohydrate residues of glycoconjugates on erythrocytes and other cell surfaces. LÄS MER

  5. 5. Optimizing sampling of important events in complex biomolecular systems

    Författare :Lindahl Viveca; Berk Hess; Erik Lindahl; Bert de Groot; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; free energy calculation; adaptive sampling; extended ensembles; membrane proteins; DNA; Biologisk fysik; Biological Physics;

    Sammanfattning : Proteins and DNA are large, complex molecules that carry out biological functions essential to all life. Their successful operation relies on adopting specific structures, stabilized by intra-molecular interactions between atoms. LÄS MER