Sökning: "radioimmunotherapy"

Visar resultat 6 - 10 av 27 avhandlingar innehållade ordet radioimmunotherapy.

  1. 6. Activity quantification based on scintillation camera imaging - Application to 111In/90Y radioimmunotherapy

    Författare :David Minarik; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radioimmunotherapy; bremsstrahlung imaging; activity quantification; SPECT; conjugate view; Yttrium;

    Sammanfattning : Radionuclide therapy (RNT), is important for the treatment of certain benign and malignant diseases. 90Y-Zevalin™ therapy has become an established method of treating patients with non-Hodgkin B-cell lymphoma. LÄS MER

  3. 7. Alpha-radioimmunotherapy with At-211: Evaluations and imaging on normal tissues and tumors

    Författare :Tom Bäck; Göteborgs universitet; []
    Nyckelord :radioimmunotherapy; astatine; RBE; renal function; GFR; imaging; targeted radiotherapy; alpha-RIT;

    Sammanfattning : Alpha-radioimmunotherapy (alpha-RIT) is an internal conformal radiotherapy at the cellular level using alpha-particle emitting radionuclides. Alpha-particles have a very short range in tissues (... LÄS MER

  4. 8. Astatine-211 and Iodine Conjugates: Radiohalogenation and Preclinical Pharmacokinetics for Targeted and Pretargeted Radioimmunotherapy

    Författare :Sture Lindegren; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; antibodies; dry-distillation; radiohalogenation; pretargeting; iodine; astatine-211;

    Sammanfattning : Endoradiotherapy using labelled tumour specific-monoclonal antibodies in the therapy of malignant disease is a therapeutic modality that is coming of age. While clearly defined tumours can be treated with surgery and/or chemotherapy, occult metastases requires adjuvant systemic treatment, e.g. LÄS MER

  5. 9. Radioimmunoimaging and Radioimmunotherapy of Prostate Cancer Preclinical evaluation of kallikrein related peptidase 2 targeting

    Författare :Oskar Vilhelmsson Timmermand; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radioimmunoimaging; radioimmunotherapy; antibody; 11B6; indium-111; lutetium-177; kallikrein related peptidase 2; hK2; PSA; prostate cancer; SPECT; KLK2; cherenkov luminescence imaging; CLI;

    Sammanfattning : Prostate cancer is one of the major causes of cancer related deaths in men in Europe and the United States. In this doctoral thesis, radioimmunoimaging and -therapy of prostate cancer was investigated pre-clinically by targeting the human kallikrein-related peptidase 2 (hK2) with radiolabelled monoclonal antibodies. LÄS MER

  7. 10. Astatine-211 radioimmunotherapy of ovarian cancer. Therapeutic efficacy, myelotoxicity, andradiation dosimetry in an animal model

    Författare :Jörgen Elgqvist; Göteborgs universitet; []
    Nyckelord :astatine; alpha-particles; monoclonal antibodies; radioimmunotherapy; ; ovarian cancer; myelotoxicity; therapeutic efficacy; radiation dosimetry; fractionation;

    Sammanfattning : Alpha-particle emitting radionuclides have recently obtained an increased attention whenconsidering new strategies for treating disseminated cancer. Astatine (211At), that emits alphaparticleswith a mean path length of 62 μm, a mean linear energy transfer (LET) of 111keV/Mum, and a half-life of 7. LÄS MER