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Visar resultat 1 - 5 av 27 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Experimental radioimmunotherapy and effector mechanisms

   Författare :David Eriksson; Torgny Stigbrand; Eva Forsell-Aronsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; apoptosis; mitotic catastrophe; caspases; cell cycle disturbances; combination treatment.; Immunology; Immunologi;

   Sammanfattning : Radioimmunotherapy is becoming important as a new therapeutic strategy for treatment of tumour diseases. Lately monoclonal antibodies tagged with radionuclides have demonstrated encouraging results in treatment of hematological malignancies. The progress in treatment of solid tumours using radioimmunotherapy, however, has been slow. LÄS MER

3. 2. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

   Författare :Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

   Sammanfattning : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. LÄS MER

4. 3. Pharmacokinetics and dosimetry in intraperitoneal radioimmunotherapy with 211At

   Författare :Elin Cederkrantz; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astatine-211; radioimmunotherapy; alpha-emitter; ovarian cancer; MX35; pharmacokinetics; dosimetry; effective dose;

   Sammanfattning : The prognosis for patients diagnosed with disseminated cancer is often poor. Radioimmunotherapy (RIT) is a new approach to treat disseminated disease. The aim is to target tumor cells with monoclonal antibodies (mAbs) labeled with radionuclides which release cytotoxic particle radiation upon decay. The radionuclide 211At, with half-life 7. LÄS MER

5. 4. Radioimmunotherapy in Experimental Head and Neck Squamous Cell Carcinoma : Tumour-targeting in vitro and in vivo

   Författare :Junping Cheng; Matti Anniko; Mats Engström; Vladimir Tolmachev; Torgny Stigbrand; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Otorhinolaryngology; squamous cell carcinoma; radioimmunotherapy; cell line; tumour targeting; radionuclide; nude mice; Otorhinolaryngologi; Otorhinolaryngology; Otorhinolaryngologi;

   Sammanfattning : Radioimmunotherapy (RIT) has been shown to be a practicable way to treat head and neck squamous cell carcinoma. A specific antibody recognizes the charasteristic structure of tumour cells when loaded with cytotoxic agents (toxins, drugs, radionuclides, etc). LÄS MER

7. 5. Development of targeted alpha therapy with Bi-213 and At-211 for the treatment of disseminated cancer

   Författare :Anna Gustafsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha particles; astatine; bismuth; MX35; ovarian cancer; polylysine; pretargeted radioimmunotherapy; radioimmunotherapy;

   Sammanfattning : Radioimmunotherapy (RIT) is a type of targeted cancer therapy. The concept behind RIT is to deliver cytotoxic ionizing radiation to tumor cells by attaching radionuclides to tumor-specific antibodies. LÄS MER