Sökning: "radiohalogens"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet radiohalogens.
1. Microdosimetry of radiohalogens in thyroid models
Sammanfattning : The radiohalogens 123I, 124I, 125I, 131I, and 211At are routinely used or proposed for diagnostic and therapeutic purposes. The different characteristics and application areas of these radioiodine isotopes, together with the possibility to bind them to the same carrier molecule, give many advantages, for example, by enabling relevant biodistribution and dosimetric studies important for dose-planning before radionuclide therapy. LÄS MER
2. Radiohalogenation of biomolecules : An experimental study on radiohalogen preparation, precursor synthesis, radiolabeling and biodistribution
Sammanfattning : Radiohalogens are widely used in nuclear medicine, both as tool for diagnostic in vivo imaging and inradionuclide therapy. This study deals with the use of radiohalogens; separation, precursor synthesis, labeling and biological behavior. LÄS MER
3. Indirect Radiohalogenation of Targeting Proteins : Labelling Chemistry and Biological Characterisation
Sammanfattning : In about half of all newly diagnosed cancer cases, conventional treatment is not adequately curative, mainly due to the failure of conventional techniques to find and kill residual cells and metastases, which might consist of only a few malignant cells, without causing unacceptable complications to healthy tissue. To solve the problem a more selective delivery of cytotoxic substances to tumour cells is needed. LÄS MER
4. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy : Preclinical Studies on Head and Neck Cancer
Sammanfattning : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. LÄS MER
5. Systemic effects after ionizing radiation exposure: Genome-wide transcriptional analysis of mouse normal tissues exposed to (211)At, (131)I, or 4 MV photon beam
Sammanfattning : The radionuclides 131I and 211At are used or proposed for a variety of cancer treatments. Both radiohalogens exhibit considerable uptake in the thyroid gland and–to a lower degree–in various other tissues if they are unbound or released from a cancer-targeting agent. LÄS MER