Sökning: "radiobiological optimization"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden radiobiological optimization.

1. 1. Development of a Whole Body Atlas for Radiation Therapy Planning and Treatment Optimization

   Författare :Sharif Qatarneh; Anders Brahme; Bengt Lind; Anders Ahnesjö; Stockholms universitet; []
   Nyckelord :3D whole body atlas; lymph node topography; matching transformation; radiation therapy planning; radiobiological optimization; segmentation; target volume definition; medicinsk strålningsfysik; Medical Radiation Physics;

   Sammanfattning : The main objective of radiation therapy is to obtain the highest possible probability of tumor cure while minimizing adverse reactions in healthy tissues. A crucial step in the treatment process is to determine the location and extent of the primary tumor and its loco regional lymphatic spread in relation to adjacent radiosensitive anatomical structures and organs at risk. LÄS MER

3. 2. Determination and use of radiobiological response parameters in radiation therapy optimization

   Författare :Panayiotis Mavroidis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Radiotherapy optimization; tumour control; normal tissue complications; radiobiological treatment planning; biological models; dose-response parameters;

   Sammanfattning : Optimization of radiation therapy is critically dependent on the use of patient related information. For this reason, radiobiological models describing the dependence of tumour and normal tissue responses on the irradiated volume and the dose-time-fractionation schedule should be introduced. LÄS MER

4. 3. Improving the therapeutic ratio of stereotactic radiosurgery and radiotherapy

   Författare :Bahram Andisheh; Bengt Lind; John Hopewell; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; optimization; stereotactic radiosurgery; stereotactic radiotherapy; radiobiology; modeling; Medical Radiation Physics; medicinsk strålningsfysik;

   Sammanfattning : New methods of high dose delivery, such as intensity modulated radiation therapy (IMRT), stereotactic radiation therapy (SRT) or stereotactic radiosurgery (SRS), hadron therapy, tomotherapy, etc., all make use of a few large fractions. LÄS MER

5. 4. Improved dose response modeling for normal tissue damage and therapy optimization

   Författare :Magdalena Adamus-Górka; Bengt K. Lind; Anders Brahme; Panayiotis Mavroidis; Randall K. Ten Haken; Stockholms universitet; []
   Nyckelord :Normal tissue complications; radiobiological models; dose-response; volume effect; spinal cord; effective FSU size; medicinsk strålningsfysik; Medical Radiation Physics;

   Sammanfattning : The present thesis is focused on the development and application of dose response models for radiation therapy. Radiobiological models of tissue response to radiation are an integral part of the radiotherapeutic process and a powerful tool to optimize tumor control and minimize damage to healthy tissues for use in clinical trials. LÄS MER

7. 5. Biological optimization of angle of incidence and intensity modulation in breast and cervix cancer radiation therapy

   Författare :Brigida Costa Ferreira; Anders Brahme; Roger Svensson; Ion Christian Chiricuta; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biological treatment planning; angle of incidence optimization; intensity modulation; breast and cervix cancer; Radiation biology; Strålningsbiologi;

   Sammanfattning : Biological treatment optimization aim at improving radiation therapy by accounting for the radiobiological tumour and normal tissues response properties when optimizing the dose delivery. Generally traditional methods, using only dosimetrical measures, disregard the nonlinear radiation response of different tumours and normal tissues. LÄS MER