Sökning: "radical scavenging"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden radical scavenging.

  1. 1. A radical view of haemoglobin - protein engineering and characterisation

    Författare :Marie Grey; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; His-Gln tagging; protein purification; blood substitutes; radical scavenging; superoxide dismutase; E. coli; diglobin; Haemoglobin; protein engineering; aqueous two-phase systems; hydrophobic interaction chromatography;

    Sammanfattning : In recent years shortages of donated blood have become a growing problem for health care systems world-wide. Blood substitutes based on human haemoglobin (Hb) could potentially ameliorate this situation. However, clinical trials have indicated problems due to e.g. LÄS MER

  3. 2. Delayed Cell Death after Traumatic Brain Injury : Role of Reactive Oxygen Species

    Författare :Fredrik Clausen; Lars Hillered; Tiit Mathiesen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Traumatic Brain Injury; Reactive oxygen species; Fluid percussion injury; Controlled cortical impact; weight drop injury; Extracellular-signal regulated kinase; apoptosis; free radical scavenging; morphology; functional outcome; Neurovetenskap; Neurology; Neurologi;

    Sammanfattning : Traumatic brain injury (TBI) is a leading cause of death and disability TBI survivors often suffer from severe disturbances of cognition, memory and emotions. Improving the treatment is of great importance, but as of yet no specific neuroprotective treatment has been found. LÄS MER

  4. 3. Cell-Penetrating Peptides for Mitochondrial Targeting

    Författare :Carmine Pasquale Cerrato; Ülo Langel; Shana O. Kelley; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial targeting; cell-penetrating peptides; antioxidant activity; scavenging ability; oligonucleotide delivery; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Mitochondria have simply been known as the cell’s powerhouse for a long time, with its vital function of producing ATP. However, substantially more attention was directed towards these organelles once they were recognized to perform several essential functions having an impact in cell biology, pharmaceutics and medicine. LÄS MER

  5. 4. A1M: a heme and radical binding protein. A study on structure, function and mechanisms

    Författare :Sigurbjörg Rutardottir; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; α1-microglobulin; oxidative stress; heme; radiation; reactive oxygen species; preeclampsia;

    Sammanfattning : This thesis describes functional and structural studies of the human protein α1-microglobulin (A1M), an evolutionarily well-conserved 26 kDa plasma and tissue protein mainly synthesized in the liver. A1M belongs to the lipocalin protein family. Lipocalins share a very similar structur, an 8-stranded β-barrel forming a hydrophobic pocket. LÄS MER

  7. 5. Mechanisms of Brain Damage Following Focal Cerebral Ischemia: Changes in Ion Homeostasis and the Importance of Free Radical Formation

    Författare :Gunilla Gidö; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBN; free radicals; potassium; extracellular calcium; neuronal damage; energy-depletion; hypoglycemia; Cerebral focal ischemia; spreading depression; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : In this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. LÄS MER