Sökning: "radiation dosimetry"

Visar resultat 21 - 25 av 80 avhandlingar innehållade orden radiation dosimetry.

1. 21. Astatine-211 radioimmunotherapy of ovarian cancer. Therapeutic efficacy, myelotoxicity, andradiation dosimetry in an animal model

   Författare :Jörgen Elgqvist; Göteborgs universitet; []
   Nyckelord :astatine; alpha-particles; monoclonal antibodies; radioimmunotherapy; ; ovarian cancer; myelotoxicity; therapeutic efficacy; radiation dosimetry; fractionation;

   Sammanfattning : Alpha-particle emitting radionuclides have recently obtained an increased attention whenconsidering new strategies for treating disseminated cancer. Astatine (211At), that emits alphaparticleswith a mean path length of 62 μm, a mean linear energy transfer (LET) of 111keV/Mum, and a half-life of 7. LÄS MER

3. 22. Computational and experimental methods for imaging and dosimetry in 177Lu radionuclide therapy : Classical and novel gamma cameras

   Författare :Daniel Roth; Lund Medicinsk strålningsfysik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Radionuklidterapi; [177Lu]Lu-DOTA-TATE; Gammakamera; Aktivitetskvantifiering; Dosimetri; CdZnTe; Monte Carlo; Radionuclide therapy; [177Lu]Lu-DOTA-TATE; Gamma camera imaging; Activity quantification; Dosimetry; CdZnTe; Monte Carlo;

   Sammanfattning : Radionuclide therapy (RNT) is a form of radiotherapy that uses unsealed radioactive sources for the delivery of ionising radiation within a patient's body.Radiation dosimetry is not used routinely in all centres, and the RNT field can benefit from more data on pharmacokinetics and absorbed doses (ADs). LÄS MER

4. 23. Realistic tissue dosimetry models using Monte Carlo simulations. Applications for radionuclide therapies

   Författare :Erik Larsson; Lund Medicinsk strålningsfysik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; internal dosimetry; radionuclide therapy; Monte Carlo; small scale dosimetry;

   Sammanfattning : Radionuclide therapy (RNT) is a generic term for treatment modalities that use a radionuclide labeled to a target-specific molecule. This so-called radiopharmaceutical accumulates in the target, where the ionizing radiation damages the cells. At sufficient levels of radiation, the cells cannot repair themselves. LÄS MER

5. 24. Studies of clinical proton dosimetry using Monte Carlo simulation and experimental techniques

   Författare :Joakim Medin; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proton dosimetry; Proton stopping power; Monte Carlo; Proton stopping-power ratios; Ionization chamber calibration; medicinsk strålningsfysik; Medical Radiation Physics;

   Sammanfattning : The present work aims at improving clinical proton dosimetry based on ionization chambers, and to bring its state of development closer to the corresponding status of conventional photon and electron dosimetry. In order to accomplish this, both theoretical and experimental methods have been used. LÄS MER

7. 25. Absorbed Dose Determination and Characteristics of Degraded Electron Beams: Application to Intraoperative Radiation Therapy

   Författare :Peter Björk; Internmedicin - epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical physics; radiology; tomography; medical instrumentation; Klinisk fysiologi; radiologi; tomografi; medicinsk instrumentering; absorbed dose distribution; output factor; stopping-power ratio; beam characteristics; Monte Carlo calculation; electron beam dosimetry; applicator system; radiation therapy; linear accelerator; intraoperative radiotherapy;

   Sammanfattning : The aim of this work was to quantify limitations of and uncertainties in commonly used dosimetric techniques for relative absorbed dose determination in degraded electron beams, such as those encountered in intraoperative radiation therapy (IORT) and small-electron-field radiotherapy. Three different detector types were investigated with regard to measurements of output factors and relative absorbed dose distributions: (1) a parallel-plate ionization chamber, (2) a p-type silicon diode detector and (3) a diamond detector. LÄS MER