Sökning: "quaternary stereocenter"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden quaternary stereocenter.

  1. 1. Synthesis of Indole Alkaloids and Development of New Methodology

    Författare :Anita Hoang; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; total synthesis; indole alkaloids; Domino reactions; vicinal quaternary stereocenters; quaternary stereocenter; indoline synthesis; communesin alkaloid; perophoramidine; dehaloperophoramidine; akuammiline alkaloids; strictamine; intramolecular Heck reaction; domino carbopalladation carbonylation; indoline alkaloids;

    Sammanfattning : This thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. LÄS MER

  3. 2. Natural Product Synthesis and Development of Novel Reaction Methodology

    Författare :Jakob Danielsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; perophoramidine; communesin; quaternary stereocenter; Diels-Alder; 1; 2-asymmetric induction; polar Felkin-Anh; Cornforth-Evans; Mukaiyama aldol; 3-dipolar cycloaddition; azomethine ylide; 2-amino alcohol; anti-α-amino-β-hydroxy ester;

    Sammanfattning : This thesis deals with the development of new reaction methodology for stereoselective synthesis, as well as total synthesis of natural products and investigations of the stereochemical outcome in the Mukaiyama aldol reaction. Chapter 2 describes efforts made towards the total synthesis of the oxindole natural products perophoramidine and the communesin. LÄS MER

  4. 3. Stereoselective Nucleophilic Additions to Aldehydes and Synthesis of α-Amino-β- Hydroxy-Esters

    Författare :Jakob Danielsson; Peter Somfai; Hans Adolfsson; Tobias Rein; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Asymmetric induction; stereochemical models; Mukaiyama; polar Felkin-Anh; Cornforth-Evans; 1; 3-dipole; aziridine; cycloaddition; amino alcohol; carbonylation; Heck reaction; quaternary stereocenter;

    Sammanfattning : This thesis deals with the development of new reaction methodology as well as stereochemical investigations. The first part concerns the investigation of 1,2- and merged 1,2- and 1,3- asymmetric induction in Mukaiyama aldol additions to α-heteroatom and α,β- heteroatom substituted aldehydes respectively. LÄS MER

  5. 4. Development of catalytic enantioselective C-C bond-forming and cascade transformations by merging homogeneous or heterogeneous transition metal catalysis with asymmetric aminocatalysis

    Författare :Samson Afewerki; Armando Córdova; MICHELANGELO GRUTTADAURIA; Mittuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric catalysis; transition metals; aldehydes; heterogeneous catalysis; amino acid; organocatalysis; α-allylation; β-alkylation; dynamic transformations; polysubstituted; carbocycles; spirocyclic oxindoles; all-carbon quaternary stereocenters;

    Sammanfattning : Chiral molecules play a central role in our daily life and in nature, for instance the different enantiomers or diastereomers of a chiral molecule may show completely different biological activity. For this reason, it is a vital goal for synthetic chemists to design selective and efficient methodologies that allow the synthesis of the desired enantiomer. LÄS MER

  7. 5. Highly enantioselective synthesis of lactam and sugar derivatives by chiral aminocatalysis and merging with transition metal catalysis

    Författare :Zhang Kaiheng; Armando Cordova; Malkov Andrei; Mittuniversitetet; []
    Nyckelord :;

    Sammanfattning : This thesis presented novel methodologies for enantioselectivesynthesis of highly functionalized lactam and sugar derivatives.Asymmetric organocatalysis, cooperative dual catalysis and one-pot multicomponent reaction strategies were applied for the construction of continuous and quaternary stereogenic center. LÄS MER