Sökning: "pyruvate dehydrogenase kinase"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden pyruvate dehydrogenase kinase.

  1. 1. Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP

    Författare :Ulrika Krus; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; Endocrinology; pyruvate dehydrogenase kinase; beta-cells; pyruvate carboxylase; diabetology; Endokrinologi; sekretion; diabetologi; diabetes;

    Sammanfattning : Type 2 diabetes is a disease that increases tremendously in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. LÄS MER

  3. 2. Bioelectrochemical Applications of Reactions Catalyzed by Immobilized Enzymes

    Författare :Xiao-Jing Tang; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Acetate Kinase.; NAD NADH recycling; Enzyme Electrodes; Enzyme reactors; Enzyme Immobilization; Electrochemical detection; Flow Injection Analysis; Analytical chemistry; Analytisk kemi;

    Sammanfattning : The sensitivity of biosensors can be increased substantially by incorporation in a substrate recycling scheme. Based on the amplification of NAD+/NADH by the recycling reaction catalyzed by glycerol dehydrogenase (GDH) and diaphorase, NAD+/NADH can be determined amperometrically with around 1000 times higher sensitivity than for the substrate sensing mode. LÄS MER

  4. 3. Protein phosphorylation in plant mitochondria

    Författare :André Struglics; Lund Ortopedi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; FoF1-ATPase; autophosphorylation; protein kinase activity; protein phosphorylation; Plant mitochondria; inner mitochondrial membrane; NDPK; Physiological biophysics; Växtfysiologi;

    Sammanfattning : Protein phosphorylation in the subcompartments of plant mitochondria was investigated by labelling with [gamma-32P]ATP and by SDS-PAGE/autoradiography. About 20 proteins in inside-out inner mitochondrial membranes from potato tubers were phosphorylated by endogenous protein kinases when incubated with [gamma-32P]ATP. LÄS MER

  5. 4. Molecular regulators of glucose and lipid metabolism in skeletal muscle

    Författare :Sameer S Kulkarni; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscle is a primary site of insulin action and insulin-stimulated glucose transport and occupies a center stage in maintaining whole body glucose and lipid homeostasis. Another key feature of a healthy skeletal muscle is its ability to switch between utilization of lipids and glucose as fuel in response to feeding or fasting respectively. LÄS MER

  7. 5. Skeletal muscle HIF-1 and exercise

    Författare :Helene Rundqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Regular physical activity prevents and improves a number of disease conditions and reduces the risk for premature death substantially. From a clinical as well as a basic science point of view it is important to create a more fundamental understanding of the molecular mechanisms that contribute to the improved functional capacity induced by regular physical activity. LÄS MER