Sökning: "pyrimidine"

Visar resultat 6 - 10 av 53 avhandlingar innehållade ordet pyrimidine.

  1. 6. Catabolism of Pyrimidines in Yeast

    Författare :Anna Rasmussen; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Pyrimidine degradation; catabolism of pyrimidines; nucleic acid precursors; yeast; Lachancea kluyveri; URC pathway;

    Sammanfattning : Pyrimidines are important precursors for nucleic acids, and constantly synthesized and degraded in the cell to maintain a balanced supply. Many microoganisms can also extract the nitrogens from the pyrimidine ring, and use them as a nitrogen source when “preferred” sources are absent. LÄS MER

  3. 7. Structural studies of drug targets and a drug metabolizing enzyme

    Författare :Daniela Cederfelt; U. Helena Danielson; Doreen Dobritzsch; Inari Kursula; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biophysics; Protein structure; X-ray crystallography; Cryogenic electron microscopy; Enzymology; Drug discovery; Pyrimidine degradation; Biokemi; Biochemistry;

    Sammanfattning : The work presented in this thesis describes how structural information about a protein can be acquired, and how it can be used to answer scientific questions about proteins’ function, their dynamic behaviour and their interactions with other proteins or ligands.The catalytic function of the pyrimidine-degrading, drug metabolizing enzyme β-ureidopropionase (βUP) is dependent on the shift between oligomeric states. LÄS MER

  4. 8. Reconstitution of Membrane-Bound Enzymes for Neutron Scattering Studies: A Case Study of Human Dihydroorotate Dehydrogenase

    Författare :Manuel Orozco; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane proteins; dihydroorotate dehydrogenase; pyrimidine metabolism; neutron scattering; ubiquinone; QCM-D;

    Sammanfattning : Membrane proteins are challenging to study due the necessity to maintain a lipid-like environment to preserve their structure and function. Particularly difficult to study are membrane-bound enzymes that interact with lipophilic substrates. LÄS MER

  5. 9. Structural and Biochemical Characterizations of Three Potential Drug Targets from Pathogens

    Författare :Lu Lu; Sherry L Mowbray; Alwyn Jones; Christian Cambillau; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LepB; DXR; NDH-2; fosmidomycin; quinolinyl pyrimidine; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : As antibiotic resistance of various pathogens emerged globally, the need for new effective drugs with novel modes of action became urgent. In this thesis, we focus on infectious diseases, e.g. LÄS MER

  7. 10. Design of pyrimidine-based photoresponsive surfaces and light induced wettability control

    Författare :Anuttam Patra; []
    Nyckelord :;

    Sammanfattning : For photochromic molecules, the ability to switch reversibly between two states is controlled largely by structural effects. The photodimerization of 5-methyluracil, commonly known as thymine, a member of the pyrimidine family and one of the DNA bases, is a particularly important reaction in photobiology, one which occurs when the molecule is subjected to UV irradiation. LÄS MER