Sökning: "purine"

Visar resultat 21 - 25 av 57 avhandlingar innehållade ordet purine.

1. 21. Development and characterization of damped cubic response functions with application to two-photon absorption

   Författare :Tobias Fahleson; Patrick Norman; Joanna Kauczor; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Molecular response to electromagnetic fields - static or optical - within a framework of perturbation theory diverges close to resonance with molecular transitionen energies, and need work-around solutions for real-valued response functions. This licentiate thesis deals with nonlinear response, with focus being on cubic polarizaibilities, and outlines the underlying mathematics for exact-state and approximatestate, complex-valued response functions applicable to quantum chemical computation. LÄS MER

3. 22. Gastro-intestinal toxicity related to haemopoietic stem cell transplantation with a special focus on the intestinal barrier function

   Författare :Jan-Erik Johansson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The myeloablative, cytotoxic therapy (conditioning treatment) prior to haemopoietic stem cell transplantation (HSCT) has the combined purpose of eliminating leukaemic or cancer cells located in the bone marrow or elsewhere in the body and, in the allogeneic setting, of suppressing the immune response of the recipient to prevent marrow rejection. The unwanted effect is the inevitable elimination of normal, haemopoietic stem cells, a lethal effect which is circumvented by the following administration of haemopoietic stem cells from the patient (autologous HSCT) or from a related or an unrelated donor (allogeneic HSCT). LÄS MER

4. 23. Molecular dynamics simulations of RNA bulges, loops and base flipping

   Författare :Boel Nyström Macchion; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are mainly double stranded while RNA molecules often have single stranded regions that interrupt the double stranded structure. LÄS MER

5. 24. Preclinical studies of roscovitine

   Författare :Marina Vita; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Roscovitine; Metabolism; Pharmacokinetics; LC-MS; Cdk-inhibitor; Toxicity;

   Sammanfattning : Cyclin-dependent kinases (Cdks) are key enzymes implicated in vital functions of the cell including regulation of the cell cycle, apoptosis, transcription and differentiation. Abnormal regulation of these molecules has been correlated to several diseases, such as cancer, viral infections, neural disorders and kidney inflammations. LÄS MER

7. 25. Structural Studies of Glutamine Synthetases – Towards the Development of Novel Antitubercular Agents

   Författare :Wojciech W. Krajewski; Sherry L. Mowbray; Torsten Unge; Thomas C. Terwilliger; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Structural biology; Strukturbiologi;

   Sammanfattning : Glutamine synthetase (GS) plays an important role in nitrogen metabolism, where it catalyzes the ATP-dependent condensation of glutamate and ammonia to yield glutamine. Recent studies showed the importance of M. tuberculosis GS (MtGS) for growth and survival of the bacterium, and demonstrated its potential as a drug target. LÄS MER