Sökning: "purine"
Visar resultat 16 - 20 av 57 avhandlingar innehållade ordet purine.
16. Metabolic regulation and anticancer drug resistance in the yeast Saccharomyces cerevisiae
Sammanfattning : Cancer is a malignant neoplastic tissue. The pyrimidine analogue 5-fluorouracil is an anticancer drug used against several types of cancer. It owes its specificity against neoplasms due to the higher rate of nutrient uptake, RNA and DNA synthesis, and in particular the higher rate of nucleobase scavenging and salvage of neoplastic cells. LÄS MER
17. Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine
Sammanfattning : The goal of this thesis has been to elucidate the mechanisms underlying resistance to methotrexate (MTX), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG), the antimetabolites widely used in treatment of childhood leukemia, as well as to determine the influence of 7-hydroxymethotrexate (7-OHMTX), the major metabolite of MTX, on the therapeutic action of MTX. Resistant sublines of leukemic cell lines were developed by long-term exposure to stepwise increasing concentrations of these different agents. LÄS MER
18. Energy-metabolic aspects of ischemia and pre-treatment: studies in porcine myocardium
Sammanfattning : The focus of this thesis is to clarify mechanisms involved in protective pre-treatment of ischemia by carbon monoxide (CO) and ischemic preconditioning (IP), so that new pro-tective therapies can be designed. This is studied in heart muscle, where the clinical gain would ultimately be to be able to prolong the period during a threatened myocardial infarction where permanent injury can be prevented. LÄS MER
19. Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei
Sammanfattning : Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs.T. LÄS MER
20. Application of copper corrosion inhibitors in mineral oil : Surface analytical studies and corrosion mitigation evaluations
Sammanfattning : This doctoral thesis explores the copper corrosion inhibiting properties of a number of nitrogen containing hetero-organic compounds in refined mineral oil. Traditional organic corrosion inhibitors, as well as novel and bioorganic compounds have been studied. LÄS MER