Sökning: "purine"

Visar resultat 11 - 15 av 57 avhandlingar innehållade ordet purine.

  1. 11. The use of allopurinol and biodynamic modeling in the quantitative assessment of purine metabolism in man

    Författare :Geert van Waeg; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 12. Targets and strategies for drug development against human African sleeping sickness

    Författare :Farahnaz Ranjbarian; Anders Hofer; Staffan G. Svärd; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T. brucei thymidine kinase; T. brucei methylthioadenosine phosphorylase; FANA-A purine nucleoside analogues; essential oils;

    Sammanfattning : Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. LÄS MER

  4. 13. Studies on oligodeoxyribonucleotide (DNA) chemistry

    Författare :Neil Balgobin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This communication discusses some of the more common problems encountered in the chemical synthesis of oligodeoxyribonucleotides. Several new protecting groups are introduced, such as the 2-phenylsulphonylethyl and the fluoren-9-methyl, for terminal phosphodiester protection, during the block synthesis of oligodeoxyribonucleotides, following the Catlin-Cramer approach. LÄS MER

  5. 14. Synthesis of Potential Inhibitors Against HIV

    Författare :Johanna Wachtmeister; Jan Kihlberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis describes the syntheses of various potential inhibitors of HIV, e.g. some 3´-hydroxymethyl-substituted carbocyclic nucleoside analogues as reverse transcriptase inhibitors and some symmetry-based peptidomimetics as protease inhibitors. LÄS MER

  7. 15. Investigation of antiviral and anticancer nucleoside analog substrate recognition of drosophila melanogaster and herpes virus deoxyribonucleoside kinases

    Författare :Nicola Solaroli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The deoxyribonucleoside kinase of the fruit fly Drosophila melanogaster (Dm-dNK) is a multisubstrate enzyme that phosphorylates pyrimidine and purine deoxyribonucleosides as well as several anticancer and antiviral nucleoside analogs. Dm-dNK is sequence related to the human deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK) and thymidine kinase 2 (M), as well as to the herpes simplex virus type-1 thymidine kinase (Hsv-1 TK). LÄS MER