Sökning: "purine analogues"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden purine analogues.

  1. 1. Regeneration of peripheral nerves: The role of protein phosphorylation

    Detta är en avhandling från Animal Physiology

    Författare :Bodil Svensson; [1996]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neurology; Djurfysiologi; Animal physiology; frog; mouse; purine analogues; MAP kinase; dorsal root ganglia; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The involvement of phosphorylation/dephosphorylation reactions in peripheral nerve regeneration was studied in frog and adult mouse during in vivo and in vitro conditions. By comparing phosphoprotein patterns in normal and regenerating frog sciatic nerves a regeneration related phosphoprotein (PP90) was found. LÄS MER

  2. 2. Targets and strategies for drug development against human African sleeping sickness

    Detta är en avhandling från Umeå : Umeå University

    Författare :Farahnaz Ranjbarian; Umeå universitet.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T. brucei thymidine kinase; T. brucei methylthioadenosine phosphorylase; FANA-A purine nucleoside analogues; essential oils;

    Sammanfattning : Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. LÄS MER

  3. 3. Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors

    Detta är en avhandling från Umeå : Umeå University

    Författare :Itedale Namro Redwan; Göteborgs universitet.; Gothenburg University.; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aminoacyl tRNA synthetases; Aminoacyl-AMP; Bioisosteres; Amino Acids; Solution-Phase; Protective Groups; Solid-Phase Chemistry; Molecular Modelling; Biological Evaluation;

    Sammanfattning : Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes present in all living organisms, their catalytic activity is involved in the translation of the genetic code into functional proteins and they are potential targets for anti-infective agents. The first step in the biosynthetic pathway catalysed by aaRSs consists of activation of the corresponding amino acid by the reaction with ATP to form an aminoacyl-adenylate (aa-AMP), the key intermediate in the biosynthesis of proteins. LÄS MER

  4. 4. Synthesis of Potential Inhibitors Against HIV

    Detta är en avhandling från Stockholm : Stockholm University

    Författare :Johanna Wachtmeister; Stockholms universitet.; [1999]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis describes the syntheses of various potential inhibitors of HIV, e.g. some 3´-hydroxymethyl-substituted carbocyclic nucleoside analogues as reverse transcriptase inhibitors and some symmetry-based peptidomimetics as protease inhibitors. LÄS MER

  5. 5. Novel Treatment of African Trypanosomiasis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology

    Författare :Suman Kumar Vodnala; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Human African Trypanosomiasis (HAT) or Sleeping Sickness is fatal if untreated. Current drugs used for the treatment of HAT have difficult treatment regimens and unacceptable toxicity related issues. LÄS MER