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  1. 1. Pulmonary hypertension. Clinical and pathophysiological studies

    Författare :Nedim Selimovic; Göteborgs universitet; []
    Nyckelord :Pulmonary hypertension; Echocardiography; Right heart catheterisation; Pulmonary vascular resistance; Pulmonary function tests; Lung transplantation; Mortality on the waiting list; Vascular remodelling; Growth substances; Inflammation; Endothelin;

    Sammanfattning : Pulmonary hypertension (PH) is a common abnormality, most often associated with various cardiopulmonary diseases. Pulmonary arterial hypertension (PAH) is a devastating pulmonary vascular disease characterised by the proliferation of endothelial, smooth-muscle cells and fibroblasts. LÄS MER

  3. 2. Vardenafil and methylarginines in pulmonary hypertension

    Författare :Anna Sandqvist; Gerhard Wikström; Jörn Schneede; Amrita Ahluwalia; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vardenafil; pulmonary hypertension; pharmacokinetics; haemodynamics; right heart catheterization; adenosine; dimethylarginines; phosphodiesterase type 5 inhibitors; endothelin receptor antagonists; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Background: Pulmonary hypertension (PH) is a rare condition characterized by endothelial dysfunction and vascular remodelling, leading to increased pulmonary vascular resistance (PVR) and right ventricular heart failure. Endothelial dysfunction is associated with an imbalance between vasoconstrictor compounds, such as endothelin and thromboxane A2, and vasodilator compounds, such as prostacyclin and nitric oxide (NO). LÄS MER

  4. 3. Acute Pulmonary Embolism : not just an acute condition after all

    Författare :Therese Andersson; Stefan Söderberg; Bo Carlberg; Bengt Zöller; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute Pulmonary Embolism; Chronic Thromboembolic Pulmonary Hypertension CTEPH ; Chronic Thromboembolic Pulmonary Disease CTEPD ; invärtesmedicin; Internal Medicine; kardiologi; Cardiology;

    Sammanfattning : Background: Acute pulmonary embolism (PE) is the third most common cardiovascular disease following myocardial infarction and stroke. Despite diagnostic improvements, the diagnosis of PE is still associated with many difficulties, as the symptoms of an acute PE are nonspecific. LÄS MER

  5. 4. Pulmonary Hypertension and the Nitric Oxide System

    Författare :Dan Henrohn; Gerhard Wikström; Ulla Lindqvist; John Pernow; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary hypertension; nitric oxide; ADMA; arginine; nitrate; nitrite; vardenafil; beetroot juice; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Pulmonary hypertension (PH) is a pathophysiological state associated with several medical conditions, leading to progressive rise in pulmonary vascular resistance (PVR) and right ventricular failure. The clinical PH classification encompasses five main World Health Organization (WHO) groups; pulmonary arterial hypertension (PAH), PH due to left heart disease, PH due to lung diseases and/or hypoxia, chronic thromboembolic PH, and PH with unclear multifactorial mechanisms. LÄS MER

  7. 5. Assessment of the right heart in pulmonary hypertension

    Författare :Anna Werther Evaldsson; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Echocardiography methods; Cardiac magnetic resonance imaging; Pulmonary hypertension; Right atrial volume; Right ventricular function; Right heart catheterization;

    Sammanfattning : .... LÄS MER