Sökning: "pulmonary delivery"

Visar resultat 6 - 10 av 41 avhandlingar innehållade orden pulmonary delivery.

1. 6. Ceramic Materials as Drug Delivery Systems

   Författare :Amina Vazda; Håkan Engqvist; Santos Hélder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug delivery; ceramics; Abuse deterrent; inhalation; single-crystals;

   Sammanfattning : The aim of this thesis is to evaluate ceramic materials for drug delivery drugs applications. Three delivery routes were investigated; abuse-deterrent oral formulation, inhalation, and novel ceramic crystals with drug entrapped. A geopolymer matrix was developed in order to withstand non-medical abuse such as crushing, snorting, extraction etc. LÄS MER

3. 7. Drug absorption in the lungs : studies in the isolated perfused rat lung model combined with physiologically based biopharmaceutics modelling

   Författare :Johanna Eriksson; Hans Lennernäs; Erik Sjögren; Helena Thörn; Ben Forbes; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary drug absorption; physiologically based biopharmaceutics modeling; pulmonary drug delivery; Biofarmaci; Biopharmaceutics;

   Sammanfattning : Pulmonary delivery of drugs is the preferred route of administration for treatment of local lung diseases like asthma and chronic obstructive pulmonary disease. Recently, there has also been increased interest in systemic delivery of drugs via the lungs to avoid problems with low and/or variable gastrointestinal absorption, and as a needle-free alternative for drugs that cannot be ingested. LÄS MER

4. 8. Effects of Microparticulate Drug Delivery Systems : Tissue Responses and Transcellular Transport

   Författare :Eva Ragnarsson; Per Artursson; Lucia Lazorova; David Brayden; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; microparticles; vaccine; pDNA vaccine; cationic polymer; gene expression analysis DNA array ; Caco-2; follicle-associated epithelium FAE ; M cell; transcytosis; Yersinia pseudotuberculosis; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Sammanfattning : Over the past decade, the development of macromolecular drugs based on peptides, proteins and nucleic acids has increased the interest in microparticulate drug delivery, i.e., the delivery of drug systems in the nanometer and micrometer ranges. LÄS MER

5. 9. Extreme hemodilution: Effects of inhalation anesthetics, hypoxia, and blood loss. An Experimental study in pigs

   Författare :Henning Schou; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology; oxygen saturation.; blood volume; coronary circulation; blood lactate; oxygen uptake; Anemia; oxygen delivery; intensive care; Anestesiologi; intensivvård;

   Sammanfattning : Hemodilution reduces the need for blood transfusion and hereby the risk for transmission of infectious agents. The present study investigated effects on systemic and myocardial circulation and oxygenation, and blood lactate concentrations; induced by nitrous oxide, isoflurane, hypoxia, and uncompensated blood loss, in pigs hemodiluted to a hematocrit of 11%. LÄS MER

7. 10. Endothelial function during ischemia-reperfusion and effects of inhalation of nitric oxide

   Författare :Lars Lindberg; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chemiluminescence; capnography; monitoring; inhalation; mechanical ventilation; pulmonary hypertension; nitric oxide; EDRF; endothelium-derived relaxation factor; endothelium; organ preservation; Lung; lung transplantation; electrochemical fuel cell; Anaesthesiology; intensive care; Anestesiologi; intensivvård;

   Sammanfattning : The vascular endothelium is an important regulatory organ in circulatory physiology and plays a central role in the response to acute inflammation and ischemia/reperfusion. Activation and dysfunction of the pulmonary vascular endothelium are closely related to clinical findings of pulmonary dysfunction. LÄS MER