Sökning: "pulmonary delivery"

Visar resultat 21 - 25 av 41 avhandlingar innehållade orden pulmonary delivery.

  1. 21. Performance of a revised capnodynamic method for cardiac output monitoring

    Författare :Thorir Sigmundsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cardiac output;

    Sammanfattning : Cardiac output (CO) monitoring is ideal for guiding fluid, vasopressor and inotropic therapy for sufficient oxygen delivery and may improve outcome in high risk surgery. In this context, many minimally-and non-invasive methods have emerged during recent years, however, they appear less reliable when compared to the thermodilution methods during rapid changes in vascular volume and resistance, a common feature during major surgery. LÄS MER

  3. 22. Oxygen sensing in myeloid cells : implications for physiology and cancer

    Författare :Miloš Gojković; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O2) through inspiration. In the lungs, O2 is gathered by erythrocytes that consequently deliver it to all cells by the cardiovascular system. O2 levels vary within our bodies. LÄS MER

  4. 23. Splanchnic organ homeostasis in experimental endotoxin shock : with special reference to the endothelin and renin-angiotensin systems

    Författare :Anders Oldner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endotoxin; endothelin; angiotensin II shock; tonometry microdialysis; porcine; hypoxanthine; gut; splanchnic circulation; lactate; mucosal pHi;

    Sammanfattning : Splanchnic organ homeostasis may become severely deteriorated in states of sepsis and endotoxaemia. Gut tissue hypoxia with subsequent increases in intestinal mucosal permeability has been proposed to contribute to the development of multiple organ failure. LÄS MER

  5. 24. A novel technology for studying the disposition of drugs and toxicants in the lung : short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols

    Författare :Pär Ewing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aerosol; inhalation; rat; lung; absorption; drugs; carcinogen; particles;

    Sammanfattning : The disposition of solutes following the deposition of inhaled substances in the lung is a complex process that proceeds along parallel paths; passive diffusion of solutes through the air/blood barrier and local metabolism followed by blood-borne clearance to the circulation. Using the isolated and perfused lung (IPL) the pulmonary disposition of inhaled particles can be studied in great detail without interference from distal organs and systemic exposure. LÄS MER

  7. 25. Spray-Dried Powders for Inhalation : Particle Formation and Formulation Concepts

    Författare :Jessica Elversson; Göran Alderborn; Anna Millqvist-Fureby; Lars Hovgaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Spray drying; Particle formation; Density; Protein formulation; Encapsulation; Coating; Competitive adsorption; Polymer; ESCA; AFM; FTIR; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : Spray drying is a method with a high potential in the preparation of protein particles suitable for pulmonary delivery. However, surface induced denaturation of bio-molecules during atomization and subsequent drying can be substantial and it is therefore important to develop new formulation concept for concurrent encapsulation and stabilization of proteins during spray drying. LÄS MER