Sökning: "pteridine"

Hittade 4 avhandlingar innehållade ordet pteridine.

  1. 1. Pteridine dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type 1

    Författare :Olov Ekwall; Uppsala universitet; []
    Nyckelord :Medical sciences; APS I; alopecia; autoantigen; cDNA; malabsorption; phenylalanine hydroxylase; pteridine; tryptophan hydroxylase; tyrosine hydroxylase; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Autoimmune polyendocrine syndrome type I (APS) is a monogenous, recessively inherited disease characterised by endocrine and non-endocrine autoimmune manifestations. One fifth of APS I patients suffer from periodic intestinal dysfunction with varying degrees of malabsorbtion, steatorrhea and constipation. LÄS MER

  3. 2. Aspects of direct method procedures for solving crystal structures : applications to isoalloxazine and pteridine derivatives and some comments on the structural chemisty of flavin compounds

    Författare :Rolf Norrestam; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  4. 3. Understanding evolutionary novelty through female-limited polymorphisms

    Författare :Kalle Tunström; Christopher W. Wheat; Rhonda R. Snook; Patrícia Beldade; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; populationsgenetik; Population Genetics;

    Sammanfattning : Understanding how novel traits evolve is a central question in evolutionary biology. However, unraveling the complex genetic and developmental mechanisms underlying trait innovation can be challenging, especially when the trait evolved a long time ago. LÄS MER

  5. 4. Drug discovery against leishmaniasis : Bio- and chemoinformatic guided strategies for target evaluation and hit identification

    Författare :Elisabet Vikeved; UCM Alsmark; Christian Sköld; David Horn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leishmaniasis; Drug discovery; Lateral gene transfer; Comparative genomics; Virtual screening; Target fishing; Marine natural products;

    Sammanfattning : Leishmaniasis is a neglected tropical disease mainly affecting poor people in developing countries. It is caused by infections of flagellated protozoa belonging to genus Leishmania. The few available drugs are associated with problems such as low effectiveness, severe side effects and resistance development. LÄS MER