Sökning: "proximity analysis"

Visar resultat 11 - 15 av 239 avhandlingar innehållade orden proximity analysis.

  1. 11. High Content Analysis of Proteins and Protein Interactions by Proximity Ligation

    Författare :Karl-Johan Leuchowius; Ola Söderberg; Ulf Landegren; Paul Goldsmith; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ; proximity ligation; flow cytometry; high content screening; rolling circle amplification; in situ PLA; single-cell; single-molecule; protein interactions; drug screening; post-translational modifications; Molecular medicine; Molekylär medicin; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Fundamental to all biological processes is the interplay between biomolecules such as proteins and nucleic acids. Studies of interactions should therefore be more informative than mere detection of expressed proteins. Preferably, such studies should be performed in material that is as biologically and clinically relevant as possible, i.e. LÄS MER

  3. 12. Det ansvarsfulla mötet : En närhetsetisk analys av omsorgens innebörder i förskolan

    Författare :Mie Josefson; Hillevi Lenz Taguchi; Sven Persson; Stockholms universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; care; responsibility; preschool; preschool teacher; ethics of care; proximity ethics; reworking qualitative data; omsorg; ansvar; förskola; förskolepedagog; omsorgsetik; närhetsetik; sekundär analys; Early Childhood Education; förskoledidaktik;

    Sammanfattning : This doctoral thesis embraces Care in the discipline of Early Childhood Education. In this thesis, the concept of responsibility is used to analyze the meaning of care in preschool. LÄS MER

  4. 13. Solid-phase Proximity Ligation Assays : High-performance and multiplex protein analyses

    Författare :Spyros Darmanis; Masood Kamali-Moghaddam; Ulf Landegren; Mathias Uhlen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; proximity ligation assay; multiplexed; biomarkers; solid-phase; microparticles; cancer; sequencing; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : Protein biomarkers circulating in blood hold the promise of improved diagnosis, prognosis and follow-up of treatment of disease via minimally invasive procedures. For the discovery and validation of such biomarkers, methods are needed that can facilitate parallel, highly specific and in-depth analysis of the blood proteome. LÄS MER

  5. 14. Development and Application of Proximity Assays for Proteome Analysis in Medicine

    Författare :Felipe Marques Souza de Oliveira; Masood Kamali-Moghaddam; Ulf Landegren; Mats Gullberg; Janne Lehtiö; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solid-phase proximity ligation assay; post-translational modifications; glycosylation; phosphorylation; Enzyme-linked immunosorbent assay; immunoassay and rolling circle amplification; Proximity Extension Assay; inflammation protein biomarkers; autoantibodies; autoimmune disease;

    Sammanfattning : Along with proteins, a myriad of different molecular biomarkers, such as post-translational modifications and autoantibodies, could be used in an attempt to improve disease detection and progression. In this thesis, I build on several iterations of the proximity ligation assay to develop and apply new adaptable methods to facilitate detection of proteins, autoantibodies and post-translational modifications. LÄS MER

  7. 15. Proximity Matters? Geographical aspects of changing strategies in automotive subcontracting relationships:the case of domestic suppliers to Volvo Troslanda assembly plant

    Författare :Anders Larsson; Göteborgs universitet; []
    Nyckelord :automotive-industry; Hydro-Raufoss Automotive; just-in-time; location; proximity;

    Sammanfattning : This study analyses the significance of geographical proximity in the restructuring process of a domestic subcontractor system in the Swedish automotive industry, using the Volvo Torslanda assembly plant as a case. The focus is on: i) the organisation of buyer-subcontractor relationships, ii) time-related delivery strategies, iii) the significance of geographical proximity. LÄS MER