Sökning: "proximity analysis"

Visar resultat 1 - 5 av 180 avhandlingar innehållade orden proximity analysis.

  1. 1. Proximity Ligation Transforming protein analysis into nucleic acid detection through proximity-dependent ligation of DNA sequence tagged protein-binders

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Simon Fredriksson; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; Proximity ligation; proteomics; SELEX; antibody; DNA microarray; Molekylärmedicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Molecular medicine genetics and pathology ; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Molekylär medicin genetik och patologi ; Molecular Medicine; molekylär medicin genetik och patologi ;

    Sammanfattning : A novel technology for protein detection, proximity ligation, has been developed along with improved methods for in situ synthesis of DNA microarrays. Proximity ligation enables a specific and quantitative transformation of proteins present in a sample into nucleic acid sequences. LÄS MER

  2. 2. Proximity Ligation and Barcoding Assays Tools for analysis of proteins and protein complexes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Di Wu; Uppsala universitet.; Uppsala universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; proximity barcoding assay; sensitive; in situ; multiplex; profiling; amyloid-beta; MARK; tau; CSF; biomarker; protein complexes; Alzheimer’s disease; amyotrophic lateral sclerosis; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. LÄS MER

  3. 3. Proximity Ligation Assays for Disease Biomarkers Analysis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Rachel Yuan Nong; Uppsala universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; blood biomarkers; protein interactions; pathway analysis; single molecule; next-generation sequencing; Molekylär medicin; Molecular Medicine;

    Sammanfattning : One of the pressing needs in the field of disease biomarker discovery is new technologies that could allow high performance protein analysis in different types of clinical material, such as blood and solid tissues. This thesis includes four approaches that address important limitations of current technologies, thus enabling highly sensitive, specific and parallel protein measurements. LÄS MER

  4. 4. Geographic Accessibility Analysis - Methods and Application

    Detta är en avhandling från Real Estate Science, Department of Technology and Society, Lund University

    Författare :Anders Dahlgren; [2008]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; GIS; geographic accessibility; proximity analysis; spatial index; generalization of graphs; network search;

    Sammanfattning : Geographic accessibility to services is important. Having a grocery store and a school nearby are important living conditions and having a rescue station close by could be a life-saver. LÄS MER

  5. 5. Bank branches and Entrepreneurship A spatial analysis of new firm formation in Swedish regions and industries in a changing financial landscape

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Cynthia Sin Tian Ho; KTH.; [2019]
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; New firm formation; entrepreneurship; financing; bank branches; proximity; spatial analysis; GWR; Sweden; Företagsekonomi; Business Studies;

    Sammanfattning : The purpose of this thesis is to analyse how bank branch closure has affected the formation of new firms and to explore the varying local relationships between the accessibility of bank branches and new firm formation in 290 Swedish municipalities. In the first paper, the effect of bank branch closure is examined through spatial econometric analysis, in particular, the fixed effects and the random effects spatial panel models. LÄS MER