Avancerad sökning

Visar resultat 1 - 5 av 74 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Choreography of a proton pump : Studies of charge-transfer reactions in cytochrome c oxidase

    Författare :Jóhanna Vilhjálmsdóttir; Peter Brzezinski; Joachim Heberle; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; heme-copper oxidase; cytochrome c oxidase; respiration; proton pump; electron transfer; proton transfer; proton-transfer pathway; midpoint potential; proton-pumping mechanism; Biochemistry; biokemi;

    Sammanfattning : In the last step of cellular respiration, electrons from metabolites are transferred to molecular oxygen, mediated by the enzyme complexes of the respiratory chain. Some of these enzyme complexes couple these redox reactions to formation of an electrochemical proton gradient across the cell membrane. The proton gradient is used e.g. LÄS MER

  3. 2. Electron and proton transfer in cytochrome c oxidase

    Författare :Magnus Brändén; Peter Rich; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytochrome c oxidase; electron transfer; proton transfer; proton; Biochemistry; Biokemi; biokemi; Biochemistry; Biophysics; biofysik;

    Sammanfattning : This doctoral thesis describes results from studies on the mechanisms by which the enzyme cytochrome c oxidase catalyses the reduction of oxygen to water. Cytochrome c oxidase is the last integral enzyme complex of the socalled respiratory chain in the mitochondrial inner membrane (plasma membrane of bacteria). LÄS MER

  4. 3. Proton pump inhibitors: indications and acid rebound

    Författare :Anna Niklasson; Göteborgs universitet; []
    Nyckelord :Proton pump inhibitors; indications; gastrointestinal symptoms; overuse; chronic obstructive pulmonary disease; acid rebound hypersecretion; gastroesophageal reflux disease;

    Sammanfattning : Proton pump inhibitors (PPIs) are nowadays the therapy of choice in the management of a variety of upper gastrointestinal (GI) conditions particularly gastroesophageal reflux disease (GERD). Previous studies indicate that patients commonly receive PPIs without clear indications. LÄS MER

  5. 4. Regulation of proton-coupled electron transfer in cytochrome c oxidase : The role of membrane potential, proton pathways and ATP

    Författare :Markus Björck; Peter Brzezinski; Thorsten Friedrich; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; charge transfer; membrane potential; membrane protein; mitochondria; ATP; proton pump; Biochemistry; biokemi;

    Sammanfattning : Cytochrome c oxidase (CytcO) is the final electron acceptor of the respiratory chain. In this chain a current of electrons, derived from degradation of nutrients, along with protons, are used to reduce oxygen to water. The reaction is exergonic and the excess energy is used to pump protons across the membrane. LÄS MER

  7. 5. Nitric Oxide Reductase from Paracoccus denitrificans : A Proton Transfer Pathway from the “Wrong” Side

    Författare :Ulrika Flock; Pia Ädelroth; Simon de Vries; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; denitrification; nitric oxide reductase; heme copper oxidase superfamily; divergent member; proton transfer; electron transfer; single turnover; spectroscopy; periplasm; glutamate; proton pathway; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Denitrification is an anaerobic process performed by several soil bacteria as an alternative to aerobic respiration. A key-step in denitrification (the N-N-bond is made) is catalyzed by nitric oxide reductase (NOR); 2NO + 2e- + 2H+ → N2O + H2O. LÄS MER