Sökning: "proteomics karolinska"

Visar resultat 1 - 5 av 85 avhandlingar innehållade orden proteomics karolinska.

  1. 1. Proteomics in neurological disease

    Författare :Jan Ottervald; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurodegenerative and neuroinflammatory diseases are conditions affecting the central nervous system that in the end have dramatic impacts on the affected individuals and their families. Today, large efforts are made to understand the disease origin and progression. LÄS MER

  3. 2. Statistical methods for biomarker discovery in proteomics

    Författare :Chuen Seng Tan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Proteomics; mass spectrometry; SELDI; MALDI; peak detection; signal detection; peak annotation; transcriptomics; data integration; maximum covariance analysis; generalized singular value decomposition;

    Sammanfattning : Surface-Enhanced Laser Desorption and Ionization (SELDI) is a promising proteomic technique for discovering biomarkers. However, the pre-processing of the raw data is still problematic. LÄS MER

  4. 3. Clinical proteomics : quantitative analysis and biological interpretation

    Författare :AnnSofi Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main expectations of applying proteomics technologies to clinical questions are the discovery of disease related biomarkers. Despite technological advancement to increase proteome coverage and depth to meet these expectations the number of generated biomarkers for clinical use is small. LÄS MER

  5. 4. Membrane proteins and proteomics : un amour possible?

    Författare :Hanna Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Membrane proteins constitute 20-30 % of the human genome and make up 60 % of all drug targets. They play important roles in key cellular functions such as small molecules transport, cell-cell interactions and cell signaling. Membrane proteins and proteomics have been notoriously difficult to combine. LÄS MER

  7. 5. Mass spectrometry based proteomics : data analysis and applications

    Författare :Yafeng Zhu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mass spectrometry (MS) based proteomics has become a widely used high throughput method to investigate protein expression and functional regulation. From being able to study only dozens of proteins, state-of-art MS proteomic techniques are now able to identify and quantify ten thousand proteins. LÄS MER