Sökning: "proteolysis"

Visar resultat 21 - 25 av 144 avhandlingar innehållade ordet proteolysis.

1. 21. Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins

   Författare :Mujtaba Hassan; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Galectins; Galectin-3; Galectin-8; benzimidazole; affinity; selectivity; X-ray; PROTAC;

   Sammanfattning : Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders. LÄS MER

3. 22. On methods for probing structure and function of membrane proteins

   Författare :Erik Jansson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; proteomics; patch-clamp; mass spectrometry.; proteoliposomes; microfluidic superfusion; cholesterol; TRPV1; limited proteolysis; Membrane proteins; fluorescence;

   Sammanfattning : The determination of structure–function relationships in membrane proteins plays a key role for the understanding of molecular mechanisms in biological systems, and may provide information on how these systems can be modulated by pharmaceuticals. The aim of the work described herein was to develop methods for studying structure and function of membrane proteins, ideally in combination. LÄS MER

4. 23. The cell biology and catalytic properties of the nutrient-induced signaling endoprotease Ssy5

   Författare :António Martins; Per O. Ljungdahl; Bruno André; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nutrient sensing; signal transduction; regulated proteolysis; endoprotease; serine protease; substrate specificity; subcellular fractionation; Saccharomyces cerevisiae; Cell Biology; cellbiologi;

   Sammanfattning : Cells continuously sense and respond to changes in the presence, quality and quantity of external and internal nutrients. Specific signaling proteases have been identified based on their roles in processing or destruction of distinct sets of downstream effector proteins in response to environmental cues. LÄS MER

5. 24. Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis

   Författare :Lei Lu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Proteasome; Ubiquitin; Cancer; Neuro-degeneration; Poly-Glutamine; Apoptosis; Tripeptidyl-Peptidase II; Stress; IAP;

   Sammanfattning : The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates are degraded by the 26S proteasome, a large multicatalytic protease complex. LÄS MER

7. 25. Oxidative stress and proteolysis in the lens. Effects of anti-inflammatory drugs

   Författare :Anne Kling-Petersen; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidation NSAIDs ASA dexamethasone apoptosis GSH GSSG proteasome lens epithelial cells mouse lens cataract;

   Sammanfattning : Oxidative stress has been implied in formation of age-related cataract. The objectives of this thesis were to study redox regulation of proteolysis and oxidative/antioxidative effects of anti-inflammatory substances in human lens epithelial cells (HLEC) and intact mouse lenses. LÄS MER