Sökning: "proteoglycans"

Visar resultat 16 - 20 av 144 avhandlingar innehållade ordet proteoglycans.

1. 16. Characterization of fibroblast phenotypes in human airway remodeling

   Författare :Kristoffer Larsen; Lungbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; remodeling; General biomedical sciences; Biomedicinska vetenskaper allmänt ; fibrocytes; proteoglycans; Asthma; fibroblasts;

   Sammanfattning : Wound healing that precedes scar formation may be unbalanced under pathological conditions leading to structural changes of the tissue. At the moment, the mechanisms behind this unbalance are unclear. When these changes occur in internal organs such as the lung, they may result in organ dysfunction with fatal consequences for the patient. LÄS MER

3. 17. Tools for understanding the glycosaminoglycan biosynthesis

   Författare :Daniel Willén; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Xylosides; Glycosaminoglycans; Proteoglycans; β4GalT7; Carbohydrate synthesis; GAG priming; GAG inhibition;

   Sammanfattning : For cells to function correctly within an organism, they need different systems to communicate with each other. One crucial part of cell signaling is the proteoglycans (PGs) and glycosaminoglycans (GAGs), which are macromolecules that bind different signaling molecules and proteins necessary for processes such as growth and proliferation. LÄS MER

4. 18. Influences of in vivo and in vitro loading on the proteoglycan synthesis of articular cartilage chondrocytes

   Författare :Mikko Lammi; Markku Tammi; Jukka Finne; Tim Hardingham; Finland Kuopio University of Kuopio Department of Anatomy; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Articular cartilage; proteoglycans; loading; stress; hydrostatic pressure; biokemi; Biochemistry; cell research; cellforskning; molekylärbiologi; Molecular Biology; ortopedi; Orthopaedics;

   Sammanfattning : In this study, the biosynthesis of proteoglycans (PGs) was examined in articular cartilage of canine hip joint after long-distance running experiment and in bovine chondrocyte cultures during in vitro loading with hydrostatic pressure. In addition, new assays were developed for more sensitive quantitation of glycosaminoglycans (GAGs) and PGs. LÄS MER

5. 19. Heparan Sulfate Biosynthesis – Clues from Knockout Mice

   Författare :Johan Ledin; Lena Kjellén; John Gallagher; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; heparan sulfate; biosynthesis; gene targeting; embryonic development; proteoglycans; NDST; N-deacetylase N-sulfotransferase; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : In the extracellular space, many specialized proteins are located to support cells and to mediate cell-cell signalling. One class of such molecules is heparan sulfate (HS) proteoglycans, which are proteins with different properties and locations but all of them decorated with long unbranched HS polysaccharide chains. LÄS MER

7. 20. The role of glycoproteins in glomerular pathophysiology

   Författare :Alina Khramova; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteoglycans; Extracellular matrix; IgA nephropathy; Diabetic kidney disease;

   Sammanfattning : Chronic kidney disease (CKD) is increasing worldwide and has a prevalence of around 10%. With time patients are at risk of losing their renal function and will need dialysis or transplantation for survival. There are no specific treatments available and mechanisms behind the onset and progression of CKD are still not fully investigated. LÄS MER