Sökning: "protein-interface interactions"

Hittade 3 avhandlingar innehållade orden protein-interface interactions.

  1. 1. Protein unfolding by interfaces and interactions between polycyclic aromatic hydrocarbons

    Författare :Svetla Chakarova Käck; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; first-principles calculations; PAH; denaturation; protein-interface interactions; van der Waals interactions; lattice models; polycyclic aromatic hydrocarbons; DFT; density functional theory;

    Sammanfattning : In order to theoretically study large and complex systems, a variety of approaches that can be categorized loosely as top-down or bottom-up are followed. While our vision is to bridge the gap between these approaches and use them together in multiscale materials modeling, the present thesis is limited to give examples of each type of approach in the study of soft-matter systems. LÄS MER

  2. 2. Thermodynamics of protein-DNA interactions

    Författare :Thomas Lundbäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA-protein interactions; molecular recognition; thermodynamics; specificity.dehydration; salt dependence.;

    Sammanfattning : This thesis treats the molecular recognition between DNA-binding proteins and DNA and the way these interactions are affected by the surrounding water solution and dissolved solutes. The work involves studies on the thermodynamics of sequence specific DNA-binding of the human glucocorticoid receptor DNA-binding domain and the nonsequence specific DNA- binding of Sso7d from the archaeon Sulfolobus solfataricus. LÄS MER

  3. 3. Accelerating the discovery of drugs for Neglected Tropical Diseases using biophysical methods

    Författare :Giulia Opassi; Helena Danielson; Jenny Sandmark; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neglected Tropical Diseases; Drug Discovery; Biochemistry; Biophysics; Kinetic; Fragment Based Lead Discovery; Assay Development;

    Sammanfattning : Even though they account for 10% of the global disease burden and besides the new record of funding in 2018, tropical diseases are still neglected by the majority of pharmaceutical companies and public funding. The reason can be mostly found in the fact that for these diseases a conventional drug discovery process is often too expensive. LÄS MER