Sökning: "protein kinase"

Visar resultat 21 - 25 av 926 avhandlingar innehållade orden protein kinase.

1. 21. Roles of protein kinase C in cell death and breast cancer

   Författare :Louise Cornmark; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; protein kinase C; apoptosis; cell death; Smac; Smac mimetics; IAP; stanniocalcin-1;

   Sammanfattning : Aberrant protein kinase C (PKC) activity and expression is implicated in different malignancies. To study the role of different PKC isoforms in breast cancer the expression of PCKα, δ and ε was evaluated in breast cancer tumors. In addition the effect of siRNA-mediated knockdown of the isoforms was studied in a global gene expression analysis. LÄS MER

3. 22. Molecular characterization of protein phosphorylation in plant photosynthetic membranes

   Författare :Maria Hansson; Alexander V. Vener; Jean-David Rochaix; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein phosphorylation; photosynthesis; mass spectrometry; protein characterization; Cell biology; Cellbiologi;

   Sammanfattning : Higher plants cannot move to a more favorable place when the environmental conditions are changing. To adapt to changes in light, temperature and access to water the plants had to evolve special mechanisms at the molecular level. LÄS MER

4. 23. Using Light to Regulate the Activity of RET Kinase: Design, synthesis and evaluation of photoswitchable DFG-out RET kinase inhibitors

   Författare :Yongjin Xu; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RET kinase; kinase inhibitor; DFG-out; photoparmacology; azoheteroarene; Buchwald-Hartwig coupling; quinoline; 7-azaindole;

   Sammanfattning : Protein kinases are essential for signal transduction and regulate most cellular processes, such as metabolism, membrane transport, motility, and cell cycle. Although they play a critical role in cells and have a strong association with diseases, details of their physiologic and pathologic mechanisms remain at least partially unclear, especially the spatiotemporal dynamics of the signalling. LÄS MER

5. 24. Determining the effects of regulatory parameters on the structural dynamics of P-type ATPase membrane transporters

   Författare :Fredrik Orädd; Magnus Andersson; Magnus Wolf-Watz; Marco Cammarata; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein dynamics; regulation; time-resolved x-ray solution scattering; MD simulation; membrane protein; P-type ATPase; SERCA; CopA; HMA4; adenylate kinase; Physical Chemistry; fysikalisk kemi;

   Sammanfattning : Proteins are macromolecular machines with roles in all cellular activities and structures. The functional properties of each protein is the result of its combination of 3D-structure and inherent dynamics, and a wealth of structural and dynamic mechanisms have evolved to regulate protein activity. LÄS MER

7. 25. Structure-Function Studies of Enzymes from Ribose Metabolism

   Författare :C. Evalena Andersson; Sherry Mowbray; Phil Evans; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; activation; isomerase; kinase; potassium; product inhibition; ribose; ribose 5-phosphate; x-ray crystallography; enzyme kinetics; fluorescence spectroscopy; protein structure; Molekylärbiologi; Molecular biology; Molekylärbiologi;

   Sammanfattning : In the pentose phosphate pathway, carbohydrates such as glucose and ribose are degraded with production of reductive power and energy. Another important function is to produce essential pentoses, such as ribose 5-phosphate, which later can be used in biosynthesis of nucleic acids and cofactors. LÄS MER