Sökning: "protein kinase B PKB Akt"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden protein kinase B PKB Akt.
1. Hormone-Sensitive Lipase and Protein Kinase B; Molecular characterization in testis, adipose tissue and pancreatic beta cells
Sammanfattning : Hormone-sensitive lipase (HSL) and protein kinase B (PKB) are enzymes that in different ways are associated with lipid metabolism. While HSL is the well-known lipolytic enzyme responsible for hydrolysis of stored triacylglycerols in adipose tissue, PKB is a recently identified serine/threonine protein kinase, ubiquitously expressed and involved in signal transduction pathways induced by insulin and growth factors. LÄS MER
2. Molecular mechanisms of insulin resistance with special emphasis on IRS-1 and PKB/Akt
Sammanfattning : .... LÄS MER
3. PKB/Akt kinase localization and role in stemness maintenance in cancer
Sammanfattning : Cancer incidence rates have increased over the last decade. Currently available therapies are only moderately effective in targeting cancer cells. Established cancer treatment protocols fail to eliminate populations of cancer stem cells (CSCs), which develop resistance against the chemotherapeutic drugs and lead to cancer recurrence. LÄS MER
4. Cisplatin-resistance and cell death in malignant pleural mesothelioma cells
Sammanfattning : Malignant pleural mesothelioma (MPM) is an aggressive, treatment-resistant tumour. Cisplatin (cis-diamminedichloroplatinum (II)) is the best single-agent chemotherapy for MPM, but platinum-based combination therapies give the best overall response rates. However, cisplatin use is limited by resistance and severe side effects. LÄS MER
5. Role of AKT/ PKB and 14-3-3 in the regulation of B cell receptor signaling and signalosome assembly
Sammanfattning : AKT/PKB is an oncogenic serine/threonine kinase regulated via the PI3K pathways. 14-3-3s represent a large group of adaptor proteins that are known to interact with a plethora of signaling proteins and regulate diverse signal transduction pathways. LÄS MER