Sökning: "protein families"
Visar resultat 21 - 25 av 272 avhandlingar innehållade orden protein families.
21. Biological data exchange and the discovery of new protein families in metagenomic samples
Sammanfattning : The rise in sequence data has brought both challenges to the way we exchange biological information and opportunities to discover new protein families, primarily through the investigation of uncultured metagenomic samples.The Distributed Annotation System, or DAS, provided a means for exchanging protein sequence data, but there were no open source, stand-alone DAS clients optimized for integrating and viewing these data. LÄS MER
22. Protein Tyrosine Phosphatases as Regulators of Receptor Ryrosine Kinases
Sammanfattning : Tyrosine phosphorylation is a crucial mechanism in cellular signaling and regulates proliferation, differentiation, migration and adhesion. The phosphorylation reaction is reversible and is governed by two families of enzymes: protein tyrosine kinases and protein tyrosine phosphatases (PTPs). LÄS MER
23. Membrane-bound proteins : Characterization, evolution, and functional analysis
Sammanfattning : Alpha-helical transmembrane proteins are important components of many essential cell processes including signal transduction, transport of molecules across membranes, protein and membrane trafficking, and structural and adhesion activities, amongst others. Their involvement in critical networks makes them the focus of interest in investigating disease pathways, as candidate drug targets, and in evolutionary analyses to identify homologous protein families and possible functional activities. LÄS MER
24. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors
Sammanfattning : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. LÄS MER
25. Hidden Markov models for remote protein homology detection
Sammanfattning : Genome sequencing projects are advancing at a staggering pace and are daily producing large amounts of sequence data. However, the experimental characterization of the encoded genes and proteins is lagging far behind. LÄS MER