Sökning: "protein chip"

Visar resultat 6 - 10 av 97 avhandlingar innehållade orden protein chip.

  1. 6. Development of Protein Microarray Chip Technology: An Outlook towards Proteomics and Diagnostics

    Författare :Anton Ressine; Avdelningen för Biomedicinsk teknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; materialteknik; Materiallära; Material technology; Teknik; Technological sciences; Naturvetenskap; Natural science; Diagnostik; Diagnostics; Medicin människa och djur ; Medicine human and vertebrates ; Biomedicinska vetenskaper; Biomedical sciences; water repellency; superhydrophobicity; proteolitic digestion; MALDI-TOF MS; bioassay; porous silicon; biomarker; diagnostics; protein microarrays; proteomics;

    Sammanfattning : One attractive method for monitoring biomolecular interactions in a highly parallel fashion is the use of microarrays. Microarrays can be applied for screening proteins which makes it an attractive tool in clinical diagnostics, drug discovery studies and basic protein research; even though many methodological challenges and ones relating to the quality control of microarrays still need to be solved. LÄS MER

  3. 7. Molecular Mechanisms of the DEK Protein in Leukemia

    Författare :Carl Sandén; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DEK; DEK-NUP214; fusion gene; acute myeloid leukemia; proliferation; mTOR; ChIP-seq;

    Sammanfattning : The DEK gene is upregulated in a growing number of cancers and translocated to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. In this thesis, we studied the cellular and molecular functions of the DEK and DEK-NUP214 proteins. LÄS MER

  4. 8. Biomarker detection via lab-on-a-chip integrated immunoaffinity approach for fluorescence and mass spectrometry readout

    Författare :Asilah Ahmad Tajudin; Avdelningen för Biomedicinsk teknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; immunoaffinity; affinity prefractionation; immunoMALDI; solid-phase extraction; protein digestion; ISET; antibody microarray; signal amplification; fluorescence; microfluidics; lab on a chip; separation; acoustophoresis; ultrasound; acoustic radiation force; plasma; proteomics; MALDI mass spectrometry; immunoassay; porous silicon.;

    Sammanfattning : The blood/plasma protein biomarker profile represents the pathological and physiological changes relating to human diseases. However, the plasma proteome reflects a high degree of complexity that results in a challenge for most analytical methods in clinical diagnostics. LÄS MER

  5. 9. OSTE Microfluidic Technologies for Cell Encapsulation and Biomolecular Analysis

    Författare :Xiamo Zhou; Wouter van der Wijngaart; Ellis Meng; KTH; []
    Nyckelord :Microfluidics; microfabrication; cell encapsulation; core-shell particle; microparticle synthesis; off-stoichiometry-thiol-ene; OSTE; OSTE ; lab-on-a-chip; surface modification; core-shell particle co-synthesis; microar- ray; micromixer; bonding; surface modification; droplet microfluidics; protein screening.; Mikrofluidik; mikrofabrikation; cellinkapsling; cores-shell kap- sel; mikrokapselsyntes; lab-on-chip; ickestökiometrisk tiol-en; OSTE; OSTE ; ytmodifiering; samtidig syntes av core-shellkapslar; mikroarray; mikromixer; sammanfogning; dropletmikrofluidik; proteindetektion.; Tillämpad medicinsk teknik; Applied Medical Technology;

    Sammanfattning : In novel drug delivery system, the encapsulation of therapeutic cells in microparticles has great promises for the treatment of a range of health con- ditions. Therefore, the encapsulation material and technology are of great importance to the validity and efficiency of the advanced medical therapy. LÄS MER

  7. 10. Macromolecules at Interfaces

    Författare :Helén Larsericsdotter; Sven Oscarsson; Jos Buijs; Willem Norde; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Protein; Adsorption; Immobilization; Surface; Surface Plasmon Resonance; SPR; Mass Spectrometry; MS; Differential Scanning Calorimetry; DSC; FT ICR; Lysozyme; Bovine Serum Albumin; BSA; Myoglobin; Globular; Kemi; Chemistry; Kemi;

    Sammanfattning : In this thesis, the structure and stability of globular proteins adsorbed onto nanometer-sized hydrophilic silica particles were investigated using differential scanning calorimetry (DSC), hydrogen/deuterium exchange (HDX), and mass spectrometry (MS). The adsorption process itself was characterized with fluorescence and absorption spectroscopy and surface plasmon resonance (SPR). LÄS MER