Sökning: "protein chip"

Visar resultat 1 - 5 av 97 avhandlingar innehållade orden protein chip.

  1. 1. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells

    Författare :Ola Wallerman; Claes Wadelius; Jussi Taipale; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP; ChIP-chip; ChIP-seq; transcription factors; motif discovery; nucleosome positioning; HepG2; genome-wide; RNA-seq; Medical genetics; Medicinsk genetik; Medical Genetics; Medicinsk genetik;

    Sammanfattning : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. LÄS MER

  3. 2. Miniaturized Techniques for Protein Analysis

    Författare :Johan Sjödahl; KTH; []
    Nyckelord :Proteins; peptides; proteases; Antarctic krill; Euphausia superba; capillary electrophoresis; fluorosurfactants; mass spectrometry; nanoelectrospray; ESI; MALDI; chip; high-throughput; reproducibility; sensitivity; mass accuracy;

    Sammanfattning : Proteins are a highly diversified group of molecules, andfor their study, advanced analytical tools are required. Inparticular, a need for high-throughput techniques has emergedin order to enable the characterization of large sets ofproteins. LÄS MER

  4. 3. Protein Microarray Chips

    Författare :Goran Klenkar; Bo Liedberg; Brian MacCraith; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microarray; biosensor; biomolecular interaction; narcotics detection; imaging ellipsometry and surface plasmon resonance; Molecular biophysics; Molekylär biofysik;

    Sammanfattning : Livet tas för givet av de flesta. Det finns däremot många som ägnar stora delar av sitt liv för att försöka lösa dess mysterier. En del av lösningen ligger i att förstå hur alla molekyler är sammanlänkade i det gigantiska nätverk som definierar den levande organismen. LÄS MER

  5. 4. Towards Myosin Powered Lab-on-a-Chip Devices

    Författare :Lasse ten Siethoff; Alf Månsson; Miklos Kellermayer; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; myosin; actin; molecular motors; lab-on-a-chip; nanobiotechnology; bionanotechnology; diagnostics; nanowires; nanowire arrays; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Myosins are protein motors that use chemical energy in the form of adenosinetriphosphate to produce force and motion. These molecular motors might be usedto power transportation in Lab-on-a-chip devices where a series of laboratory tasks(e.g. separation, concentration and detection) are performed in one sequence on asmall chip. LÄS MER

  7. 5. Design of antibody microarrays for global profiling of membrane proteins and soluble proteins

    Författare :Linda Dexlin Mellby; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scFv; membrane proteins; proteomics; protein chip; recombinant antibodies; Antibody microarray; protein profiling; membrane proteomics;

    Sammanfattning : Antibody-based microarrays have emerged as an established proteomic technology allowing multiplexed and sensitive profiling of complex proteomes, in a high-throughput and miniaturized manner. Recently, numerous applicative efforts have been pursued generating disease-associated protein signatures that now could be further explored for improved disease diagnostics, prognostics and classification. LÄS MER