Sökning: "protein carbonyls"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden protein carbonyls.

  1. 1. Oxidative Damage in Fish Used as Biomarkers in Field and Laboratory Studies

    Författare :Bethanie Carney Almroth; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fish; oxidative stress; antioxidant enzymes; glutathione; protein carbonyls; lipid peroxidation; biomarkers; pollution; aging;

    Sammanfattning : Many toxic xenobiotics entering into the aquatic environment exert their effects through redox cycling. Oxidative stress, incorporating both antioxidant defences as well as oxidative damage, is a common effect in organisms exposed to xenobiotics in their environment. LÄS MER

  2. 2. Oxidative stress, antioxidative defence and outcome of gestation in experimental diabetic pregnancy

    Författare :Jonas Cederberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pregnancy; rat; ROS; free oxygen radicals; TBARS; isoprostanes; protein carbonyls; embryo; vitamin C; vitamin E; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Maternal type 1 diabetes is associated with an increased risk for foetal malformations. The mechanism by which diabetes is teratogenic is not fully known. Previous studies have demonstrated that radical oxygen species can contribute to the teratogenicity of glucose and diabetes. LÄS MER

  3. 3. Protein Damage Control during Embryonic Stem Cell Differentiation: Role of the Proteasome

    Författare :Malin Hernebring; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Embryonic Stem Cells; Proteasome; Protein Carbonylation; Advanced Glycation End products; Cell Differentiation; Oxidative stress; Aging; RNAi;

    Sammanfattning : During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromolecular damage. However, these organisms produce youthful progeny with low damage levels. This thesis focuses on how this is accomplished. LÄS MER

  4. 4. The use of protein biomarkers in ecotoxicology : Studies of oxidative and genotoxic stress in the blue mussel (Mytilus edulis)

    Författare :Andreas Prevodnik; Michael Tedengren; Tomas Bollner; Kari Lehtonen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Ecotoxicology; ekotoxikologi;

    Sammanfattning : Many environmental pollutants, heavy metals and polyaromatic hydrocarbons (PAHs) among them, are toxic by oxidative stress. Oxidative stress may be defined as a state in an organism when its inherent capacity to handle oxyradicals is surpassed, and it may result in peroxidation of lipids, and damage to proteins and DNA. LÄS MER

  5. 5. Molecular recognition and dynamics in proteins studied by NMR

    Författare :Johan Wallerstein; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Chemical exchange; Conformational entropy; Entropy; Galectin-3; Isothermal Titration Calorimetry; ITC; Model-free formalism; Molecular recognition; Nuclear Magnetic Resonance; NMR; PGB1; Protein dynamics; Protein–ligand interactions; Proton-transfer reactions; Spin relaxation; Viscosity; Chemical exchange; Conformational entropy; Entropy; Galectin-3; Isothermal Titration Calorimetry; ITC; Model-free formalism; Molecular recognition; Nuclear Magnetic Resonance; NMR; PGB1; Protein dynamics; Protein–ligand interactions; Proton-transfer reactions; Spin relaxation; Viscosity;

    Sammanfattning : Knowledge of dynamics in protein is very important in the description of protein function and molecular recognition. The thesis investigates protein dynamics on time-scales from milli- to sub-nanosecond, with focus on the latter, using NMR spin relaxation experiments on two proteins, the 138-residue carbohydrate recognition domain of galectin-3 (Gal3C) and the 56-residue B1 domain of bacterial protein G (PGB1). LÄS MER