Sökning: "protease activity"

Visar resultat 1 - 5 av 216 avhandlingar innehållade orden protease activity.

  1. 1. Design and Synthesis of Serine and Aspartic Protease Inhibitors

    Författare :Fredrik Wångsell; Ingemar Kvarnström; Olle Karlsson; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; metathesis; HCV; NS3; protease; proline isosteres; inhibitor; aspartic protease inhibitors; hydroxyethylene; Organic synthesis; Organisk syntes;

    Sammanfattning : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. LÄS MER

  3. 2. Cyclic Sulfamide HIV-1 Protease Inhibitors : Design, Synthesis and Modelling

    Författare :Anna Ax; Anders Karlén; Anders Hallberg; Tommy Liljefors; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; AIDS; HIV; protease inhibitor; aspartic protease; molecular modelling; 3D-QSAR; CoMFA; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Ten years ago, the first protease inhibitor targeting the human immunodeficiency virus (HIV) was approved for clinical use. Highly active antiretroviral therapy (HAART), which combined protease and reverse transcriptase inhibitors, quickly became the standard therapy for treating patients infected with HIV and Acquired Immune Deficiency Syndrome (AIDS). LÄS MER

  4. 3. Design and synthesis of HIV-1 protease inhibitors

    Författare :Mathias Alterman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV-1; Protease; Inhibitors; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Sammanfattning : Human Immunodeficiency Virus (HIV) is the causative agent of Acquired Immune Deficiency Syndrome (AIDS). The C2-symmetric HIV-1 protease is one of the prime targets for chemotherapy in the treatment of the HIV infection. Inhibition of HIV-1 protease leads to immature and non-infectious viral particles. LÄS MER

  5. 4. Design and Synthesis of Malarial Aspartic Protease Inhibitors

    Författare :Karolina Ersmark; Anders Hallberg; Michael Rowley; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; malaria; plasmepsin; aspartic protease; protease inhibitor; macrocycle; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. LÄS MER

  7. 5. Characterization of conjugated protease inhibitors

    Författare :Erika Billinger; Gunnar Johansson; Boris Turk; Uppsala universitet; []
    Nyckelord :Serine protease inhibitors; conjugation; immobilization; leupeptin analogues; potato serine protease inhibitor; soluble carriers; inorganic carriers.; Biokemi; Biochemistry;

    Sammanfattning : The overall theme of this thesis is a step by step approach for the design and characterization of conjugated protease inhibitors. This involves both a new assay method for protease activity and protease inhibition (paper I), a study of the stoichiometry for protease inhibitor interaction (paper II), design of inhibitory peptides (paper IV) and the construction of inhibitor conjugates (paper III & IV). LÄS MER