Sökning: "prostate-specific antigen"

Visar resultat 6 - 10 av 85 avhandlingar innehållade orden prostate-specific antigen.

  1. 6. A New Look into Protein C Inhibitor : Posttranslational Modifications and their Functions

    Författare :Wei Sun; Sophia Schedin Weiss; Hakon Leffler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein C inhibitor; posttranslational modifications; N-glycan; O-glycan; mass spectrometry; factor Xa; thrombin; prostate specific antigen; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : The influences of posttranslational modifications on the functions of the versatile serpin protein C inhibitor (PCI) were studied. PCI is a serine protease inhibitor that is expressed in many tissues and secreted to various fluids in human, including blood plasma, seminal plasma, and urine. LÄS MER

  3. 7. Genetic, environmental and life-style effects on androgen receptor function

    Författare :Christel Björk; Malmö Molekylärgenetisk reproduktionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproductive function; smoking; 4 .4-DDE; persistent organic pollutants; prostate cancer; Androgen receptor; prostate specific antigen; CAG polymorphism; TCDD; aryl hydrocarbon receptor; CB-153;

    Sammanfattning : Androgens regulate male reproductive function and their effects are mediated through the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. LÄS MER

  4. 8. Prostate Cancer Screening - Aspects of Overdiagnosis

    Författare :Rebecka Arnsrud Godtman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; active surveillance; age; cause of death; opportunistic; organized; overdiagnosis; prostate cancer; prostate-specific antigen; risk factors; screening; screening interval;

    Sammanfattning : The overall aim of this thesis is to explore aspects of overdiagnosis, i.e. the diagnosis of a tumor that in the absence of screening would never have been diagnosed, in prostate cancer (PC) screening. LÄS MER

  5. 9. Early diagnosis and treatment of prostate cancer : observational studies in the National Prostate Cancer Register of Sweden and the Västerbotten Intervention Project

    Författare :Benny Holmström; Pär Stattin; Håkan Jonsson; Mattias Johansson; Gunnar Aus; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; prostate-specific antigen; single nucleotide polymorphism; Urology and andrology; Urologi och andrologi; Urology; kirurgi; särskilt urologi;

    Sammanfattning : Prostate-specific antigen (PSA) testing has caused a steep increase in the incidence of prostate cancer, especially the incidence of localised low risk disease. In order to decrease the overdiagnosis accompanied by PSA testing, analysis of inherited genetic variants have been suggested as potential tools for clinical assessment of disease risk. LÄS MER

  7. 10. The Kallikrein-Related Peptidases hK2 and PSA with Emphasis on Genetic Variation, Secretion, and Sperm Motility

    Författare :Charlotta Sävblom; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human glandular kallikrein 2; KLK3; hk2; prostate-specific antigen; PSA; sperm motility; seminal plasma; androgen receptor; SNP; CAG; KLK2;

    Sammanfattning : Prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) are secreted by the prostate into seminal plasma and through leakage into blood. This leakage increases rapidly in prostate disease, and PSA is used worldwide as a marker of prostate cancer. LÄS MER