Sökning: "prostate-specific antigen"

Visar resultat 36 - 40 av 85 avhandlingar innehållade orden prostate-specific antigen.

  1. 36. Miniaturised and Quantitative Techniques Targeting Prostate Cancer

    Författare :Kerstin Järås; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The prostate-specific antigen (PSA) test used in the clinic today has been subjected to suspicions regarding specificity and sensitivity, since cases of benign prostatic hyperplasia or prostatitis are hard to distinguish from those with prostate cancer. This thesis is based upon five original papers describing efforts to develop antibody microarrays enabling improved diagnostic prostate cancer analysis. LÄS MER

  3. 37. Clinical pharmacokinetic/pharmacodynamic modelling of 5a-reductase inhibitors for the treatment of benign prostatic hyperplasia

    Författare :Per Olsson Gisleskog; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : Dihydrotestosterone (DHT), a potent androgen necessary for the development of benign prostatic hyperplasia (BPH) is formed from testosterone by the enzyme 5α-reductase, of which there are two types. The irreversible 5α-reductase inhibitors dutasteride, which inhibits both isozymes, and finasteride, which inhibits only one, are intended for the treatment of BPH. LÄS MER

  4. 38. Dendritic cells in immune and gene therapy against cancer

    Författare :Andreas Lundqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dendritic cells; immunotherapy; gene therapy;

    Sammanfattning : Dendritic cells (DC) are extensively used for vaccine therapy due to their superior T cell stimulatory capacity. However, the modest therapeutic effects reported by most clinical trials using DC, together with the rapid developing field of DC biology suggests important considerations for improvement of the clinical outcome. LÄS MER

  5. 39. Radioimmunoimaging and Radioimmunotherapy of Prostate Cancer Preclinical evaluation of kallikrein related peptidase 2 targeting

    Författare :Oskar Vilhelmsson Timmermand; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radioimmunoimaging; radioimmunotherapy; antibody; 11B6; indium-111; lutetium-177; kallikrein related peptidase 2; hK2; PSA; prostate cancer; SPECT; KLK2; cherenkov luminescence imaging; CLI;

    Sammanfattning : Prostate cancer is one of the major causes of cancer related deaths in men in Europe and the United States. In this doctoral thesis, radioimmunoimaging and -therapy of prostate cancer was investigated pre-clinically by targeting the human kallikrein-related peptidase 2 (hK2) with radiolabelled monoclonal antibodies. LÄS MER

  7. 40. Neoadjuvant hormone treatment in localized prostate cancer : a clinical and histopathological study

    Författare :Magnus Hellström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Localized prostate cancer; radical prostatectomy; neo-adjuvant androgen deprivation; GnRH-agonist; histopathology; immunohistochemistry; image analysis; cancer volume; DNA ploidy patterns; PSA in serum; follow-up; prognosisStockholm 1996;

    Sammanfattning : Surgical treatment of localized prostate cancer may be hampered by the spread of cancer through the prostate capsule and in the surgical margins. The prostate is dependent on androgen hormones for its growth and function. LÄS MER