Sökning: "prostanoids"

Visar resultat 16 - 20 av 21 avhandlingar innehållade ordet prostanoids.

  1. 16. Talking to the Brain at the Blood-Brain Barrier through Inflammation-Induced Prostaglandin E2

    Författare :Ana Maria Vasilache; Camilla Nilsberth; Sivert Lindström; Fredrik Elinder; Ted Ebendal; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The immune-to-brain signaling is a critical survival factor when the body is confronted by pathogens, and in particular by microorganisms. During infections, the ability of the immune system to engage the central nervous system (CNS) in the management of the inflammatory response is just as important as its ability to mount a specific immune response against the pathogen, since the CNS can provide a systemic negative feed-back to the immune activation by release of stress hormones and also can prioritize the usage of the energy resources by the vital organs. LÄS MER

  3. 17. Prostaglandin modulation of airway hyperresponsiveness and inflammation in murine models of asthma

    Författare :Linda Swedin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Allergic asthma is an inflammatory disease of the airways and is characterised by chronic inflammation, reversible bronchoconstriction and airway hyperresponsiveness (AHR). The cyclooxygenases (COXs) are key enzymes in the biosynthesis of prostaglandins, which have diverse physiological and pathological functions, and are also important modulators of inflammatory responses in the lung. LÄS MER

  4. 18. mPGES-1 : a key regulator of fever and neonatal respiratory depression

    Författare :Sipra Saha; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostaglandins are potent lipid mediators, synthesized de novo from arachidonic acid (AA) upon cell activation. AA is oxidized by the cyclooxygenase isoenzymes (COX-1 and COX-2) to form PGH2, the common substrate for downstream enzymes involved in prostaglandin biosynthesis. LÄS MER

  5. 19. Experimental studies of lipid mediator modulation of airway responsiveness

    Författare :Willem Abma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lipid mediators play an important role in responsiveness of the airways. The roles of prostanoids and leukotrienes in inducing airway inflammation and contraction are reasonably well established. LÄS MER

  7. 20. Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target

    Författare :Patrick Leclerc; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The inducible prostaglandin (PG) E2 pathway is defined by the concerted activities of the enzymes cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 in producing PGE2. PGE2 has pro-inflammatory and immunomodulatory functions and is involved in an array of diseases with an autoimmune and chronic inflammatory component, including rheumatoid arthritis (RA). LÄS MER