Sökning: "prostaglandin dehydrogenase PGDH"

Hittade 3 avhandlingar innehållade orden prostaglandin dehydrogenase PGDH.

  1. 1. Mediators of cervical ripening in preterm birth : experimental and clinical investigations

    Författare :Susanne Abelin Törnblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervix; preterm; cervical ripening; cytokines; chemokines; cyclooxygenase COX ; prostaglandin dehydrogenase PGDH ; induction; labour; nitric oxide; PgE2-gel; pregnancy; preterm labour;

    Sammanfattning : Background: Preterm birth (PTB) is by far the leading worldwide cause of infant mortality and morbidity. Despite decades of research, the frequency of PTB has not decreased and the basic mechanisms initiating the onset of labour are still poorly understood. Vaginal preterm birth cannot take place without cervical softening and remodelling. LÄS MER

  3. 2. Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target

    Författare :Patrick Leclerc; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The inducible prostaglandin (PG) E2 pathway is defined by the concerted activities of the enzymes cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 in producing PGE2. PGE2 has pro-inflammatory and immunomodulatory functions and is involved in an array of diseases with an autoimmune and chronic inflammatory component, including rheumatoid arthritis (RA). LÄS MER

  4. 3. Role of the brain derived neurotrophic factor and inflammatory mediators in colon cancer

    Författare :Syrina Mehrabi; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colon Cancer; Neutrophils; Inflammation; CysLT1R; BDNF; Tumor microenvironment; Prognostic; Predictive; Diagnostic; Gene signature; Biomarkers;

    Sammanfattning : CRC is one of the most common causes of cancer death in the world. If CRC is diagnosed in the early stages, the patient's chance of survival is estimated at about 90%, with a very low probability of recurrence. The five-year DFS for CRC patients in stage III and IV drops to 63.3% and 18. LÄS MER