Sökning: "prostaglandin E2"

Visar resultat 21 - 25 av 104 avhandlingar innehållade orden prostaglandin E2.

  1. 21. Structure and function of microsomal prostaglandin E synthase-1

    Författare :Sven-Christian Pawelzik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glutathione-dependent enzyme microsomal prostaglandin E synthase-1 (MPGES1) plays a pivotal role in inflammatory diseases. MPGES1 is up-regulated by pro-inflammatory cytokines in concert with cyclooxygenase (COX) -2, and the concerted action of both enzymes leads to the production of induced prostaglandin E2 (PGE2), a potent lipid mediator of inflammation, pain, and fever. LÄS MER

  3. 22. Prostaglandin E synthases in periodontitis-affected gingival tissue and in gingival fibroblasts

    Författare :Tove Båge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :c-Jun N-terminal kinase;

    Sammanfattning : Periodontitis is a chronic inflammatory disease resulting in the destruction of the tissue and alveolar bone supporting the teeth and leading ultimately to tooth loss. Prostaglandin E2 (PGE2) is an important inflammatory mediator in the pathogenesis of periodontitis. LÄS MER

  4. 23. Prostaglandin modulation of airway hyperresponsiveness and inflammation in murine models of asthma

    Författare :Linda Swedin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Allergic asthma is an inflammatory disease of the airways and is characterised by chronic inflammation, reversible bronchoconstriction and airway hyperresponsiveness (AHR). The cyclooxygenases (COXs) are key enzymes in the biosynthesis of prostaglandins, which have diverse physiological and pathological functions, and are also important modulators of inflammatory responses in the lung. LÄS MER

  5. 24. Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1 : inhibition and mechanism

    Författare :Linda Spahiu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) is a family of six membrane bound proteins with different biological functions. MAPEG superfamily members enable and catalyze reactions where reactive lipid intermediates are either transformed to physiological messengers or turned into unreactive compounds. LÄS MER

  7. 25. Expression of prostaglandin E synthase-1 in periodontitis : in vivo and in vitro studies

    Författare :Anna Kats; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Periodontitis is a chronic inflammatory disease characterized by destruction of the supporting structures of the teeth, including gingival tissues and alveolar bone. In advanced cases of periodontitis the ultimate clinical outcome is tooth loss. LÄS MER