Sökning: "prostaglandin D2"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden prostaglandin D2.
1. Dopamine D2 and D3 receptors. Studies on transduction mechanisms and on the role of a D3 gene polymorphism
Sammanfattning : The neurotransmitter dopamine has been implicated in the pathophysiology of, e.g., Parkinson s disease and schizophrenia, and dopamine receptor-active compounds are commonly employed therapeutically in these and other disorders. LÄS MER
2. Prostaglandin E2 as mediator and modulator of airway smooth muscle responses
Sammanfattning : Prostaglandin E2 (PGE2) is a lipid mediator produced by virtually every cell of the human body. Because common non-steroidal anti-inflammatory drugs (NSAIDs) inhibit its biosynthesis, PGE2 is usually considered to be a ‘pro-inflammatory’ mediator. The role of PGE2 in the lung and airways has however always been unclear. LÄS MER
3. Mast cell activation in response to osmotic and immunological stimulation with focus on release of eicosanoid mediators
Sammanfattning : Mast cells are important in asthma and other inflammatory diseases. Subjects with asthma have been found to have an increased number of mast cells in their airway smooth muscle and this was related to airway sensitivity. LÄS MER
4. Structural and functional studies of L-PGDS and SMPDL3A, enzymes in lipid signaling family
Sammanfattning : Enzymes are indispensable in maintaining the biological system. They metabolize complex molecules to supply nutrients, to produce energy, to regulate transcription of gene expression, and to control the concentration of effective signaling molecules in a cell, thus maintaining the homeostasis of biological system. LÄS MER
5. Human eosinophils and their activation by allergens via danger signal receptors
Sammanfattning : Human eosinophilic granulocytes are polymorphonuclear cells with a powerful arsenal of cytotoxic substances in their granules, which are mainly found in the gastrointestinal mucosa, and the respiratory and genitourinary tracts. Their physiological role is incompletely understood, although it is likely they protect the mucosal surfaces, perhaps by recognizing danger signals present on microorganisms or released from damaged tissue. LÄS MER
