Sökning: "promoter polymorphisms"
Visar resultat 11 - 15 av 81 avhandlingar innehållade orden promoter polymorphisms.
11. The role of telomerase reverse transcriptase (TERT) in human malignancies : genetic regulation and telomere lengthening-independent oncogenic activities
Sammanfattning : Telomerase is a ribonucleoprotein enzyme maintaining telomere length. Telomerase reverse transcriptase (TERT), which acts as a catalytic unit, is tightly repressed in differentiated human cells while activated in cancer cells for telomere lengthening. LÄS MER
12. Genetic Variation and Expression of the IRF5 Gene in Autoimmune Diseases
Sammanfattning : The interferon regulatory factor 5 (IRF5) gene encodes a transcription factor that plays an important role in the innate as well as in the cell-mediated immune response. The IRF5 gene has received considerable attention since it was shown to be associated with two autoimmune diseases; systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). LÄS MER
13. Candidate gene analyses and genome-wide screens in multiple sclerosis
Sammanfattning : Specific disease causing mutations have been identified for many disorders. Most of these disorders are of Mendelian origin and there have been very few successful attempts in the genetic dissection of complex traits. LÄS MER
14. Identification of the susceptibility genes in type 1 diabetes and diabetic nephropathy
Sammanfattning : Genetic susceptibility plays an important role in the pathogenesis of type 1 diabetes (T1D) and diabetic nephropathy (DN). The present study aims to investigate the association between single nucleotide polymorphisms (SNPs) in candidate genes and DN. LÄS MER
15. Search for susceptibility loci and candidate genes for breast cancer
Sammanfattning : Breast cancer is the most frequent cancer among women in the western world. Family history is a wellestablished and important risk factor for breast cancer. Both a population-based twin study and a study based on a large family cancer database have suggested that hereditary factors account for about a quarter of breast cancers. LÄS MER