Sökning: "promoter polymorphisms"
Visar resultat 1 - 5 av 78 avhandlingar innehållade orden promoter polymorphisms.
- Detta är en avhandling från Department of Microbiology, Immunology and Glycobiology, Lund University
Sammanfattning : It has been known for a long time that the clinical manifestations of urinary tract infections (UTI) differ markedly between individuals, ranging from a sometimes beneficial, asymptomatic state to life threatening infections. This variability in clinical manifestation can be explained in part by the arsenal of virulence factors of the bacteria but the predisposition of the patient is equally important. LÄS MER
- Detta är en avhandling från Division of Microbiology, Immunology and Glycobiology - MIG
Sammanfattning : Urinary tract infections (UTIs) present an interesting and relevant model for studying microbial adaptation. After establishing significant numbers, the bacteria either cause severe disease, or an asymptomatic carrier state resembling the normal flora at other mucosal sites. LÄS MER
3. The role of telomerase reverse transcriptase in human malignancies : genetic polymorphisms and promoter mutationsDetta är en avhandling från Stockholm : Karolinska Institutet, Dept of Medicine, Solna
Sammanfattning : Telomerase is a ribonucleoprotein with its catalytic subunit telomerase reverse transcriptase (TERT) as a key component, lengthening telomeres. In differentiated human cells, telomerase is silent due to the transcriptional repression of the TERT gene, but activated in oncogenesis. LÄS MER
- Detta är en avhandling från Department of Clinical Sciences, Lund University
Sammanfattning : Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the general population, and a major cause of morbidity and mortality. Low-grade inflammation, erythrocyte volume variation, and subclinical atherosclerosis have repeatedly been associated with cardiovascular disease, but it remains unclear whether these risk factors are also associated with incident AF. LÄS MER
- Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis
Sammanfattning : Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune disorder characterized by a failure in the mechanism of self-tolerance and production of autoantibodies, potentially affecting any organ in the body. The genetic factors behind the disease have been extensively studied in the past years and to date a list of more than 30 loci have been associated with SLE. LÄS MER