Sökning: "promoter polymorphisms"

Visar resultat 1 - 5 av 77 avhandlingar innehållade orden promoter polymorphisms.

  1. 1. Influence of host genetics on innate immunity and susceptibility to urinary tract infection

    Detta är en avhandling från Department of Microbiology, Immunology and Glycobiology, Lund University

    Författare :Bryndis Ragnarsdottir; Lund University.; Lunds universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; IRF3; Innate Immunity; urinary tract infections; acute pyelonephritis; asymptomatic bacteriuria; Toll-like receptor 4; CXCR1; TLR4 adaptors; polymorphisms;

    Sammanfattning : It has been known for a long time that the clinical manifestations of urinary tract infections (UTI) differ markedly between individuals, ranging from a sometimes beneficial, asymptomatic state to life threatening infections. This variability in clinical manifestation can be explained in part by the arsenal of virulence factors of the bacteria but the predisposition of the patient is equally important. LÄS MER

  2. 2. Mechanisms of microbial-host interaction during asymptomatic bacteriuria

    Detta är en avhandling från Division of Microbiology, Immunology and Glycobiology - MIG

    Författare :Jenny Grönberg Hernandez; Lund University.; Lunds universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asymptomatic bacteriuria; Urinary tract infection; Escherichia coli 83972; IRF3; TLR4; Evolution; host response; promoter polymorphisms; transcription; P fimbriae; Type 1 fimbriae;

    Sammanfattning : Urinary tract infections (UTIs) present an interesting and relevant model for studying microbial adaptation. After establishing significant numbers, the bacteria either cause severe disease, or an asymptomatic carrier state resembling the normal flora at other mucosal sites. LÄS MER

  3. 3. The role of telomerase reverse transcriptase in human malignancies : genetic polymorphisms and promoter mutations

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Författare :Xiaotian Yuan; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Telomerase is a ribonucleoprotein with its catalytic subunit telomerase reverse transcriptase (TERT) as a key component, lengthening telomeres. In differentiated human cells, telomerase is silent due to the transcriptional repression of the TERT gene, but activated in oncogenesis. LÄS MER

  4. 4. Novel risk factors for atrial fibrillation in an urban population

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Samuel Adamsson Eryd; Lund University.; Lunds universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ceruloplasmin; atrial fibrillation; epidemiology; genetic polymorphisms; intima-media thickness; plasma proteins; red blood cell distribution width; risk factors;

    Sammanfattning : Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the general population, and a major cause of morbidity and mortality. Low-grade inflammation, erythrocyte volume variation, and subclinical atherosclerosis have repeatedly been associated with cardiovascular disease, but it remains unclear whether these risk factors are also associated with incident AF. LÄS MER

  5. 5. Functional Role of Genetic Polymorphisms Associated with Systemic Lupus Erythematosus

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara E Löfgren; Uppsala universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; systemic lupus erythematosus; genetic association; single nucleotide polymorphism; IRF5; CD226; miR-146a; Medical Science; Medicinsk vetenskap; Medical Genetics; Medicinsk genetik;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune disorder characterized by a failure in the mechanism of self-tolerance and production of autoantibodies, potentially affecting any organ in the body. The genetic factors behind the disease have been extensively studied in the past years and to date a list of more than 30 loci have been associated with SLE. LÄS MER