Sökning: "proinsulin"

Visar resultat 21 - 25 av 48 avhandlingar innehållade ordet proinsulin.

  1. 21. Atherosclerosis and Insulin Resistance AIR A cross-sectional study of 58-year old men

    Författare :Lena Bokemark; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; intima-media thickness; LDL particle size; atherosclerosis.;

    Sammanfattning : The main aim of the study was to test the hypothesis that insulin resistance is associated with atherosclerotic disease in the carotid and femoral arteries as measured using the ultrasound technique in clinically healthy 58-year old men with varying degrees of obesity and insulin resistance. The subjects were recruited from the general population and were free from clinical cardiovascular disease, diabetes mellitus and treatment with antihypertensive, lipid-lowering and anti-diabetic drugs (n=818). LÄS MER

  3. 22. Genetic design for facilitated production of human peptide hormones inEscherichia coli

    Författare :Per Jonasson; KTH; []
    Nyckelord :;

    Sammanfattning : Genetic strategies have become important in the design ofefficient processes for production of recombinant proteins.When constructing a production scheme, inherent properties,purity and quality requirements, as well as the final use ofthe protein, have to be considered. LÄS MER

  4. 23. Plasminogen Activator Inhibitor-1 and the Insulin Resistance Syndrome

    Författare :Liisa Byberg; Anders Hamsten; Uppsala universitet; []
    Nyckelord :Medical sciences; PAI-1; insulin sensitivity; physical activity; birth weight; fatty acids; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Geriatrics; geriatrik;

    Sammanfattning : In this thesis, different aspects of the insulin resistance syndrome in relation to plasminogen activator inhibitor-1 (PAI-1) activity are investigated in a longitudinal population-based study. Participants were men investigated at ages 50 and 70 with follow-up data on mortality. LÄS MER

  5. 24. CFTR in pancreatic islets

    Författare :Anna Edlund; Diabetes - öcellsexocytos; []
    Nyckelord :CFTR; CF; CFRD; Cystic fibrosis; Cystisk fibros; Diabetes; Insulin; Beta cell; Glukagon; Glucagon; Alpha cell; Alfa-cell; Anoctamin; ANO1; ANO;

    Sammanfattning : AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. LÄS MER

  7. 25. On the pharmacodynamics, pharmacokinetics and metabolism of sulphonylurea and its metabolites - with special reference to glibenclamide

    Författare :Anders Jönsson; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; Endokrinologi; secreting systems; diabetology; Endocrinology; diabetologi;

    Sammanfattning : The pharmacodynamics (PD), pharmacokinetics (PK) and metabolism of the sulphonylurea(SU) and its metabolites (M1 and M2) , and of another SU, glipizide (Gz) were studied in diabetes patients and healthy volunteers. In one study Caucasians and Chinese were compared. LÄS MER