Sökning: "progression"

Visar resultat 21 - 25 av 2043 avhandlingar innehållade ordet progression.

  1. 21. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

    Författare :Steve Choy; Maria Kjellsson; Mats Karlsson; Willem de Winter; Andrea Mari; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. LÄS MER

  3. 22. p53 and neoplastic progression in Barrett's esophagus

    Författare :Stig Ramel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Barrett s esophagus; neoplastic progression; flow cytometry; p53 gene; p53protein; 17p allelic loss; p53 mutations; S phase fractions; aneuploidy; SV 40 large T antigen; elastase-SV 40 T antigen transgenic mice.;

    Sammanfattning : Barrett's esophagus is a condition in which the normal squamous epithelium is replaced by columnar epithelium as a response to acid reflux. It develops as a complication in 10-20% of patients with gastroesophageal reflux disease. LÄS MER

  4. 23. Integrin-interacting proteins in human cancer progression

    Författare :Zhengwen An; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Integrins are the major transmembrane receptors for the extracellular matrix (ECM) which regulate a diverse array of cellular functions crucial to tumor cell migration, invasion, proliferation and survival. Integrins contact the ECM via their N-terminal extracellular domains and connect to the intracellular environment via the C-terminal cytoplasmic domains. LÄS MER

  5. 24. Tumor acidosis in malignant progression and therapy

    Författare :Paola Pellegrini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer still represents one of the leading causes of death despite the advances achieved during the past years. Improving the outcome of cancer patients requires the identification of more affective therapeutic strategies and a better understanding of the molecular mechanisms involved in the progression of the disease. LÄS MER

  7. 25. Prognosis and progression in chronic kidney disease

    Författare :Marie Evans; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Analgesics; Chronic Kidney Disease; Epidemiology; Dialysis; Glomerular Filtration Rate; Lead Metal Exposure; Survival;

    Sammanfattning : Chronic kidney disease (CKD) is a life threatening condition with high risk of pre-term death and need for dialysis. The population prevalence of CKD has been estimated to 10-13% for both Europe and the USA. LÄS MER