Sökning: "progression"

Visar resultat 16 - 20 av 2043 avhandlingar innehållade ordet progression.

1. 16. Lower Urinary Tract symptoms in women – Aspects on epidemiology and treatment

   Författare :Anna Lena Wennberg; Göteborgs universitet; []
   Nyckelord :Urinary incontinence; Overactive bladder; Lower urinary tract symptoms; Epidemiology; Prevalence; Incidence; Progression; Twins; Genetic; Heritability;

   Sammanfattning : Lower urinary tract symptoms in women – aspects on epidemiology and treatment Lower urinary tract symptoms (LUTS) are common conditions that compromise a person’s quality of life and result in increased health care costs for society. The aims of this thesis were to describe the prevalence and natural course of different LUTS in women (Paper I), to assess prevalence changes over time (Paper II), and to evaluate the importance of genetic factors on LUTS (Paper III). LÄS MER

3. 17. Genomic analysis of primary and metastatic malignant melanoma

   Författare :Katja Harbst; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; next-generation sequencing; microarray; progression; molecular grade; subtype; melanoma;

   Sammanfattning : “Cutaneous melanoma is a most unpredictable lesion” wrote Alexander Breslow in 1970. He was one of the first to predict outcome in melanoma patients, based on the thickness of the primary tumor, and today this parameter bears his name and remains the main prognostic factor in melanoma. LÄS MER

4. 18. Role of MYCN in retinoblastoma : From carcinogenesis to tumor progression

   Författare :Hanzhao Zhang; Finn Hallböök; Johan Holmberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MYCN; retinoblastoma; RNA sequencing; cancer; avian; E2F; carcinogenesis; Developmental Neurosciences; Medicinsk utvecklings- och neurobiologi;

   Sammanfattning : Retinoblastoma, a pediatric malignancy of the retina, is primarily driven by the bi-allelic inactivation of the RB1gene. However, a subset of cases are characterized by proficient RB1 functions but with MYCN copy number mutations, suggesting an alternative oncogenic mechanism in the absence of RB1 mutations. LÄS MER

5. 19. Cervical dysplasia and cervical cancer in pregnancy: diagnosis and outcome

   Författare :Cecilia Kärrberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cervical dysplasia; cervical cancer; pregnancy; colposcopic scoring system; regression; persistence; progression; HPV DNA test; HPV mRNA E6 E7 test; p16INK4a;

   Sammanfattning : ABSTRACT:Cervical cancer is one of the most common types of cancer that is diagnosed during pregnancy. The primary aim in investigation of atypical cervical cytology during pregnancy is to exclude cancer so that further treatment of the lesion can be postponed until after delivery. LÄS MER

7. 20. Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression

   Författare :Siti Maisharah Sheikh Ghadzi; Maria C. Kjellsson; Mats O. Karlsson; Sandra Visser; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometric; type 2 diabetes mellitus; impaired glucose tolerance; prediabetes; anti-diabetes drug development; insulin; glucose; natural diabetes disease progression; lifestyle intervention; short-term provocation; long-term effect; glucose homeostasis; glucose and insulin regulation; weight; dropout; Pharmaceutical Science; Farmaceutisk vetenskap; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

   Sammanfattning : Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM.The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. LÄS MER