Sökning: "prodynorphin"
Visar resultat 11 - 13 av 13 avhandlingar innehållade ordet prodynorphin.
11. Proteasome targeted therapy in arthritis models : effects on pain and inflammation
Sammanfattning : The ubiquitin proteasome system (UPS) regulates numerous cellular functions by selectively degrading cellular proteins. It controls activation of the transcription factor NF-ĸB which is involved in the expression of pro-inflammatory mediators. The UPS regulates neuronal signalling by controlling levels of synaptic proteins during chronic pain. LÄS MER
12. In vitro and postmortem studies of the brain opioid system : association to opiate dependence
Sammanfattning : Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a central role in mediating the effects of opiates and related opioid. LÄS MER
13. Opioid and non-opioid activities of the dynorphins
Sammanfattning : Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein prodynorphin (PDYN). Dynorphins regulate pain processing and memory acquisition and modulate reward induced by intake of addictive substances. LÄS MER